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Hard FX (112 caps) By: Anabolic Xtreme

Hard FX: Hardcore Testosterone Activator!

Anabolic Xtreme Hard FX kicks up test levels quickly and you can actually feel it! Unlike some testosterone boosters that take a while and simply suppress estrogen levels, HardFX at Psupplements delivers results quickly and effectively allowing for more reps in the gym and more muscle gain out of the gym. Hard FX delivers results fast and may massively up-regulate seven biological mechanisms of testosterone biosynthesis and enhancement.

Hard FX works on jacking up testosterone levels quickly rather than waiting 2-3 weeks for you to feel it like some other less effective testosterone boosting supplements on the market. Why wait if you don't have to? Hard FX contains an immediate kick start built directly into the formula for fast and immediate results the very first week.

Hard FX from Anabolic Xtreme is designed to help athletes harness the power of testosterone and harden up with more quality muscle while potentially scorching away body fat at the same time. One of the biggest questions and challenges we faced in formulating Hard FX was, "How do we create a formula that will provide powerful anti-estrogen and testosterone boosting effects...without using any of the traditional and steroidal-structured aromatase inhibitors?" Traditional anti-estrogens function primarily by inhibiting the aromatase enzyme to lower estrogen, resulting in an increase in testosterone production. Despite being incredibly powerful, that's right about where their mode of action stops.

So to start we needed an aromatase inhibitor or (AI) that could rival the effects a traditional and steroidal structured AIs, and we have found one that 1) can certainly hold its own in a knock down brawl against the best, and 2) is completely natural. "Natural" AI's are typically pretty wimpy compared to steroidal AI's, but not this one. In fact, it shares near equal potency to one of the strongest traditional AIs when measured on the IC50 and Ki value scales. So what is it? Hard FX features 7-MF, an all natural and incredibly powerful flavones that exhibits strong aromatase inhibiting properties, has superior bio-availability, and is very resistant to hepatic metabolism.

7-methoxyflavone (7-MF) however is NOT to be confused with methoxyISOflavone; an ecdysteroid successfully used in livestock, but which failed miserably when used in humans. 7-MF effectively binds to the aromatase enzyme. When the aromatase enzyme is blocked, estrogen concentrations lower and testosterone biosynthesis is kicked into overdrive. We knew that Hard FX was off to a great start, but we wanted to create a formula that optimized more than one pathway of testosterone biosynthesis.

Pushing the Boundaries of Innovation Once Again! After successfully uncovering a new and naturally powerful AI to fuel Hard FX, we included another brand new, never before seen, naturally occurring key alpha isomer ingredient. This ingredient, D-Aspartic acid, has been shown in emerging human studies to deliver almost 50% more testosterone production in just over 2 weeks! In addition, it has been shown to boost luteinizing hormone (LH) levels by an average of 46% in just 13 days. And, animal studies suggest that D-Aspartic acid can also significantly elevate HGH output, which happens to occur through the same biological processes in humans. At this point we then looked at all the other pathways that contributed to testosterone biosynthesis. There's a lot, including one pathway that if ever damaged, can have a catastrophic effect on total testosterone production.

What resulted is an extremely powerful and perfectly balanced formula that massively up-regulates and enhances not one, but seven powerful pathways of testosterone biosynthesis and enhancement. Those pathways include using a natural AI to lower estrogen, increasing free testosterone, maximizing luteinizing hormone output, and increasing the production of StAR protein, PKA, cAMP, and cGMP.

Never before has a complete testosterone activator been unleashed with the sole intent to help athletes harden up with more quality muscle and potentially less body fat.

And, Hard FX is the FIRST formula to feature the brand new, naturally occurring powerhouse, D-Aspartic acid, which cannot found anywhere else at this time! We know that you will be thrilled with your results.

Within Your First Few Days of taking Hard FX it begins to activate and up-regulate seven powerful mechanisms of testosterone biosynthesis, and you may be thinking to yourself "could this stuff really be working this fast?" That's because natural testosterone boosters are generally slow to start, taking a full 2-3 weeks before you notice results. However, Hard FX has a strong kick-start built right into the formula, and it will not be uncommon to notice results within the first few days. You may also begin to notice the first signs of enhanced sexual desire. Your muscles may begin to feel denser and harder as you hit the weights and crush through set after set.

After 1 Week:
By now Hard FX has immersed your body with higher and higher levels of rising testosterone biosynthesis, and what you previously thought may have been placebo effect has become crystal clear that is it not. You know that Hard FX is working and you begin to feel unstoppable; ready and able to work out harder than you ever have before. Your muscles feel dense, full, and thick, and your working sets are feeling easier.

After 2-3 Weeks and Beyond:
Without a shadow of a doubt, you know that there is nothing else like Hard FX. It kicks in fast and is unrelenting from day 1. Your body is dynamically accelerating testosterone production and building new muscle tissue at the cellular level fast. Every single week you can see your body composition transforming. Also, don't be alarmed if you notice a definite increase in testicular size or significant increase in semen volume. At this point, it's to be expected since your body's steroidogenic pathways are receiving strong support. After 2-3 weeks, you know that you are finally on your way to achieving a harder physique with more lean mass and less fat.

Applied Performance Stack + FREE AN Gym Bag! By: Applied Nutriceuticals

For a LIMITED TIME ONLY, Buy Together and SAVE BIG BUCKS!!!

Each Stack Includes the Following:

1X Drive (110 caps)
1X RPM (110 caps)
1X NeoVar JumpStart (110 caps)
1X FREE Applied Nutriceuticals Gym Bag

DRIVE™ by Applied Nutriceuticals™

Ask yourself the simple question: If you could create the ultimate sports supplement to boost your body and achieve higher performance, what would you want it to do?

If your answer includes:
•    Increase muscle strength & speed
•    Increase endurance
•    Promote lean muscle growth
•    Speed recovery time
•    Enhance sexual performance
•    Improve mood

…then we have your prescription for achieving these results!

DRIVE by Applied Nutriceuticals is simply the most versatile performance-enhancing sports supplement available. Whether it’s packing an inch of girth on your arms or shaving a second off your best time, DRIVE provides the goods to help you get there.

The synergistic compilation of constituents contained in this unique compound creates a very favorable anabolic environment through a variety of different mechanisms:
•    Combines cGMP and cAMP synergism
•    Increased thyroid activity
•    Aromatase inhibiting effects
•    SHBG inhibition
•    Increased luteinizing hormone activity
•    Improved testosterone:estrogen and testosterone:cortisol ratios.

Dosage Chart
Body Weight (lbs.)    Dose (2x Daily)
Up to 150    1 Capsule (2 Daily)
200    2 Capsules (4 Daily)
250    3 Capsules (6 Daily)

The processes are complex, but the outcome is simple: You’ll feel better, look better and be better at what you do best! Take a test DRIVE today!

RPM: Radical Performance Maximizer!

RPM™ – A Breakthrough Pre-Workout formula in a class by itself: It is the world’s first Anabolic-Cognitive Energy System Enhancer (A-CESE): (Anabolic + Cognitive Psy-Stimulant)

RPM delivers:
•    Explosive energy without the jitters
•    Intense mental focus
•    Measurable strength increases
•    Unparalleled pumps
•    Suppressed estrogen
•    Increased testosterone
•    Thermogenic fat metabolization

RPM mimics the mechanisms and effects of experimental pharmaceutical-grade compounds called SARMs (Selective Androgen Receptor Modulators) which are being touted as a future class of drugs that will effectively replace traditional anabolic preparations due to their absence of negative side-effects.

All of this is accomplished using 100% safe herbal preparations in its ingredient profile.

Results are noticed from the very first dose, plus RPM provides positive cumulative effects with continued use.

Neovar JumpStart (110 caps): Next Generation Creatine for Maximum Cellular Recovery!

By combining the latest principles of nutritional technology with ancient Ayurvedic medicine, Applied Nutriceuticals research and development team has developed the most potent and biologically efficient post-workout nutrient enhancement product on the market. A precisely proportioned combination of Phosphocreatine and creatine monohydrate (Mono/PCr complex™) is the primary element, which plays a vital role in cellular energy production by regenerating ATP in skeletal muscle and makes it available for explosive exercises (1-5). Another important component of NeoVar, Corosolic Acid is extracted from the Banaba plant, a medicinal herb that grows in India, Southeast Asia, and the Philippines. It has been used for centuries as a treatment for hyperglycemia and diabetes, and the hypoglycemic effect is chemically very similar to that of the hormone insulin (7-11). Insulin is a polypeptide anabolic storage hormone, and is a crucial hormone in creatine transport and is necessary for the deposition of creatine phosphate in skeletal muscle. NeoVar also adds a high-quality extract of gymnema sylvestra, an herb native to central India, where it has been used as a natural treatment for diabetes for over 2,000 years. Gymnemic acid, the main active constituent of gymnema, has anti-sweetener, anti-inflammatory, and anti-diabetic attributes and its effects also closely mimic those of insulin (13-16). Bioperine® (piperine 95%) is also included in the formulation and has been shown in clinical studies to enhance the uptake of amino acids and many other nutrients, allowing protein, carbohydrates, creatine, and other nutrients to be more avaliable to supply hard-working muscle (40). The final component of NeoVar, D-Pinitol, is a cutting-edge compound that enhances nitric oxide production and insulin sensitivity which are key factors in nutrient transport. D-Pinitol has also been shown in human studies to enhance intramuscular creatine deposition in human clinical studies (30). The individual effects of these compounds combine synergistically to produce a dramatic positive impact on the strength, size, and endurance of skeletal muscle tissue.

The theory behind the synergism of the Mono/PCr Complex is quite simple: It aims to match the CRfree 40/PCr 60 ratio of the naturally occurring human skeletal intramuscular creatine pool as closely as possible; allowing for greater absorption and utilization with minimal waste. The product is blended to maximize PCr levels, while at the same time including monohydrate due to its high molar percentage of creatine as the active ingredient. Human skeletal muscle creatine stores are comprised of approximately 40% in the free creatine form (CRfree), while the remaining 60% is in the phosphorylated form; creatine phosphate (CP). The Mono/PCr complex in NeoVar essentially feeds both CRfree levels and phosphocreatine levels in this optimized ratio, which is chemically identical to what is stored in the working muscles (1,3-5). Several animal studies have confirmed that CRfree has better availability for site phosphorylation for the production of ATP, and further studies are currently underway on the validation of this theory in humans. Similarly, research on phosphate has concluded that it has numerous benefits in the athletic realm even without creatine, especially in terms of buffering lactic acid during explosive exercise. Phosphate supplementation raises levels of 2,3-diphosphoglycerate (2,3-DPG), the enzyme that unloads oxygen into muscle. Research has shown that phosphate supplementation reliably raises blood levels of 2,3-DPG, and also improves the production and use of glycogen for fuel Therefore, this blend of both CRfree and PCr could allow skeletal muscle to “recognize” and assimilate the creatine in a more refined manner, allowing for a significant degree of uptake enhancement in skeletal muscle tissue (32-38). Additionally, the insulin mimetic compounds included in the formula may even further enhance these benefits.

A recent trend in creatine supplementation has been the development of exotic esters and alkaline/time-released delivery systems. In developing NeoVar, we researched virtually every creatine derivative currently available before arriving with the final formulation. We analyzed numerous and often conflicting studies regarding the benefits of each and found many of the so-called improvements actually reduced the effectiveness of the products they were used in. Ultimately we elected to avoid this trend, which is proving to be more about company’s efforts to differentiate their products than actual effectiveness. Some of our findings include:

1. Many of the esters and delivery systems included in some of the newer products can be potentially difficult for the body to metabolize; the creatines included in NeoVar are essentially pure creatine, water, and phosphate and contain no other byproducts that could potentially hinder utilization.

2. Esters are simply fatty acid chains attached to a parent substance (in this case, creatine) that delay absorption and/or release; the newer esterified creatines actually contain less creatine, and more fatty acid chains that have no use in any type of physiological process. Several low-quality products use versions with longer esters and are only 20-30% creatine, with the rest being useless fatty acids.

3. Recent human research studies have proven that many of the alkaline creatine delivery systems actually do not work as well as creatine phosphate or creatine monohydrate as far as absorption in the digestive system and ultimately in skeletal muscle (43).

In developing NeoVar, we sought to use the molecules proven in numerous human studies to replicate the exact physiological ratios found in the intramuscular creatine pool in human skeletal muscle so the body can recognize and utilize it readily.

Creatine Phosphate Molecule

Creatine provides a variety of anabolic effects on skeletal muscle, increasing lean body mass while being a source of ATP (adenosine tri-phosphate, a source of cellular energy that aids in muscle contraction). Increased creatine phosphate inside the muscle cell is a powerful anabolic stimulus for muscle hypertrophy. Increased CP stores in the muscle allow for greater intracellular water retention. Greater intracellular water retention from increased CP raises osmotic pressure within the cell, allowing for heightened protein synthesis and nitrogen retention. Heightened protein synthesis and nitrogen retention create an optimal anabolic environment for intense muscular growth (2-4). Creatine uptake into the muscle can also be influenced by glucose, insulin and insulin-sensitizing agents, as the correct manipulation of these entities can allow for much larger amounts of creatine to be stored within the muscle cells. This is the main goal of NeoVar- to allow for the greatest amounts of creatine to be stored in working muscle through the manipulation of different nutrients, because as we all know, the more creatine you can hold in your muscles, the more your muscles will recover and grow (1-6).

ATP-PCr System

Carbohydrates
Muscle Glucose

There are many other potential benefits to creatine supplementation. Creatine boosts the activity of myogenic cells, which are satellite stem cells that have the ability to turn themselves into new muscle cells if instructed to do so by the genetic code of the body. These satellite cells fuse with an adjacent damaged muscle fiber, thereby increasing myonucleii numbers necessary for growth and repair. This process of myogenic maturation is called hyperplasia, and the subsequent new muscle cells formed by hyperplasia also have the ability to enable muscle hypertrophy (growth) if combined with weight training (4).

As we know, creatine supplementation increases intramuscular creatine stores, but to greatly varying extents. Many manufacturers suggest an initial loading dose to accelerate creatine saturation within the cell; however this method commonly produces uncomfortable abdominal cramps and bloating. In the early 90's researchers discovered that ingesting creatine w/ high glycemic carbohydrates such as dextrose dramatically raised skeletal muscle concentrations of creatine beyond regular oral supplementation alone. More recent research has found that taking creatine with glucose (25-100 g), or with combinations of glucose and protein (around 30-40 grams of each macronutrient) allows for larger amounts of creatine storage due to the increased insulin secreted in response to the carbohydrate intake (1,5,6). Up to 60% increases in intracellular creatine were noted in some subjects (a 20% raise is considered normal in most studies) using these methods, but the results varied greatly (6). While moderately effective, these techniques fall short because most ingested creatine is still not absorbed. The unabsorbed creatine accumulates outside of the targeted cells, causing a multitude of negative side effects including bloating, cramping and dehydration. The objective when developing NeoVar was to discover other compounds that can further aid in greater uptake of intramuscular creatine.

The level of creatine uptake into muscle is influenced greatly by intramuscular creatine concentration and extracellular concentrations of glucose and insulin. The ingestion of high glycemic carbohydrates (such as dextrose, fructose, and sucrose) causes a large increase in blood glucose, and concurrent to this rise in blood glucose, a surge (or “spike”) of insulin is released from the pancreas in order to control the amount of sugar in the blood. Since insulin is necessary in transporting creatine and blood glucose into skeletal muscle, the increased insulin drives greater creatine uptake into muscle (1,5,6). The amount of intramuscular creatine concentration and extracellular concentrations of glucose and insulin influence the degree of absorption into the cell. This is important, in that individuals who supplement with creatine and who have low muscle creatine and phosphocreatine levels are more responsive to creatine supplementation. The additional insulin released in response to the ingestion of carbohydrates (which convert to glucose) helps drive more creatine into the cell (6).

Therefore, taking creatine with products that can safely and effectively alter insulin levels and/or sensitivity such as banaba extract and gymnema sylvestre may enhance creatine uptake and retention. While these two herbs have been used for years in Eastern medicine to control diabetes, they are very new compounds to Western science. Corosolic acid (the active ingredient in Banaba extract) and gymnemic acid (the active ingredient in Gymnema sylvestre) closely mimic insulin by SAFELY stimulating much greater glucose into cells while not allowing plasma insulin levels to increase. It has also been plausibly theorized that with this increased cellular transport of glucose, there will also be an increased transport of creatine phosphate into the cell (7-19). In some studies where they conducted direct comparisons with insulin, corosolic acid and gymnemic acid actually performed just as well as insulin at controlling blood.

Insulin Sensitivity Graphically Illustrated

sugar in patients with Type II diabetes. Therefore while corosolic acid and gymnemic acid have a mechanism of action similar to insulin, they do have a distinct advantage over insulin, in that it is not an “equal opportunity” deposition agent, like insulin. In other words, insulin can be problematic and beneficial at the same time, in that while it can increase deposition of glucose, protein and creatine into the muscles, it can also have a negative effect by increasing body fat levels. Plus, when the body produces too much insulin over time, it begins to become insensitive to the hormone, resulting in a down-regulation of insulin receptors on target tissue (7-10, 13-21).

Gymnemic acid has also been shown to interact with receptors on the tongue to decrease the sensation of sweetness in many foods. This action has been shown to reduce blood sugar and cholesterol levels in diabetic animals and humans and may provide some benefits in terms of regulating appetite control and food cravings (19,20). Research have isolated at least nine different fractions of gymnemic acid, with each fraction possessing glucose-repartitioning activity (21-24). The effect of gymnemic acid on lowering glucose levels in the blood is gradual, usually typically taking a few days. Very high doses of gymnemic acid may even help to repair the cellular damage that causes diabetes (by helping to regenerate the insulin producing beta-cells in the pancreas). Human studies on gymnema in diabetes treatment have shown significant reduction in blood glucose, glycosylated hemoglobin (an index of blood sugar control) and insulin requirements (so insulin therapy could be reduced) (23). There appears to be due to an increase in the effectiveness of insulin with gymnema, rather than causing the body to produce more – although the precise mechanism by which this occurs remains unknown. As with other natural ingredients for control of blood sugar and insulin levels, such as corosolic acid, a common “side effect” is weight loss – probably due to a combination of appetite suppression and control of food cravings (especially for carbohydrates and sweets) (19-24).

Insulin, Glucose, and Glut-4 Translocation

Corosolic Acid (the active ingredient in Banaba Extract) has been shown to increase GLUT4 translocation in human studies. GLUT4 (muscle facilitative glucose isoform 4, a transporter protein) translocation is important because GLUT4 is a transporter protein that regulates the amount of glucose allowed into skeletal muscle cells. Corosolic acid increases the ability of the body to regulate the amount of glucose coming into a cell, and in diabetic patients, this allows for greater glucose disposal in the muscle cells. This keeps plasma insulin levels the same, meaning that the intake of corosolic acid as an insulin mimicking/glucose control agent has significant nutrient repartitioning effects (7-11). In this case, nutrient repartitioning means that while creatine, glucose, and protein are being deposited in the muscle cells, fat is not being deposited in adipocytes (fat cells), as is the case with insulin (8). This is very important, because when more simple carbohydrates are ingested after a workout, it can be theorized that more blood glucose (and creatine) are deposited into the muscle. This can help the athlete retain a more positive nitrogen balance, thus enhancing recovery and building mass, making corosolic acid and gymnemic acid important components that contribute to the profound affects of NeoVar (8-10).

Bioperine®

Bioperine (piperine 95%) is a revolutionary compound that can increase the uptake of protein, amino acids, and creatine, as well as other supplements and nutrients. A simple 10-20 mg daily dose of this substance can increase the uptake of all of these components from 30-150%. Bioperine is hugely important in the formulation of NeoVar as an effective post-workout recovery and growth enhancement product, because it allows the stomach and small intestine to absorb much greater proportions of the other active ingredients in NeoVar, along with post-workout protein and carbohydrates. Bioperine also decreases the breakdown of many nutrients by the liver, allowing for greater amounts of active ingredients to stay in the bloodstream for a longer period of time; making them more available for uptake by hard-working muscles. This helps users of NeoVar recover much faster, therefore allowing for quicker gains in strength, lean muscle mass, and overall physique enhancement (40-42).

Increased Nutrient Uptake of Coenzyme Q-10 (top) and Curcumin (bottom) with Bioperine

D-Pinitol

The cutting-edge compound D-Pinitol is also an integral component of NeoVar. In recent studies, d-pinitol stimulated glucose uptake to an extent similar to that of insulin (26-30). In the presence of a low insulin concentration a synergistic effect was observed between pinitol and insulin, namely pinitol increased the effectiveness of insulin. In addition, d-pinitol can increase glycogen synthesis in the muscle cells, particularly in the absence of insulin. However, the main reason D-Pinitol truly shines in this formulation is that it has been clinically proven to enhance creatine storage in human subjects. Creatine loading alone has been reported to increase muscle creatine and phosphocreatine stores by 5 to 30% (1-4).

Percentage of creatine retained during the 3 day loading period for the placebo (P), creatine monohydrate (CM), low-dose D-pinitol (LP), high-dose D-Pinitol (HP), and pre-D-Pinitol loading (Pre-P) groups. Data are means±SD. a = p<0.05 from placebo ; b=p<0.05 from CM ; c=p<0.05 from LP ; d=p<0.05 from HP ; e=p<0.05 from Pre-P.

A study done by Greenwood in 2001 (see above) found that low-dose d-pinitol supplementation can indeed enhance whole-body creatine deposition more so than creatine alone, or creatine and high-dose d-pinitol. Another important factor to note is that this increase in creatine storage occurred completely independent of carbohydrate intake, meaning that the user could potentially have the same effects from a d-pinitol/creatine mixture as they would with a carbohydrate/d-pinitol/creatine mixture (see below) (31).

Insulin-Like Response of D-Pinitol

Essentially, NeoVar combines the benefits of the most biologically available creatines with compounds that channel them into hard-working muscle cells more quickly, efficiently and completely than any other product ever produced. Precisely dosed, and in convenient capsules, no other product delivers the goods like NeoVar…at any price.

References

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2. Juhn MS, (2003). Popular sports supplements and ergogenic aids. Sports Med. 33 (2): 921-39. PMID 12974658.

3. Powers ME et al. (2003) Creatine Supplementation Increases Total Body Water Without Altering Fluid Distribution. Journal of Athletic Training 38 (1): 44-50 PMID 12937471.

4. Dangott B, Schultz E, Mozdziak PE. (2000). Dietary creatine monohydrate supplementation increases satellite cell mitotic activity during compensatory hypertrophy. International Journal of Sports Medicine 2000 Jan (21(1) 13-16 PMID 10683092.

5. Stout JR et al. (1997) The effects of a supplement designed to augment creatine uptake on anaerobic reserve capacity. NSCA National Conference Abstract.

6. Tarnopolsky MA, Parise G, Yardley NJ et al. (2001). Creatine-dextrose and protein-dextrose induce similar strength gains during training. Med Sci Sports Exerc. 33 (12): 2044-52 PMID11740297.

7. Department of Clinical Nutrition, Suzuka University Medical Science (2004). Corosolic Acid induces GLUT4 translocation in genetically type 2 diabetic mice. Biol Pharm Bull 2004 Jul. 27(7): 1103-5.

8. Judy WV, Hari SP, Judy JS, Naguib YM, Passwater R et al. (2003). Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependant study. J Ethnopharmacol 87(1) 115-117.

9. Miura T. et al. (2006). Antidiabetic effects of corosolic acid in KK-Ay in diabetic mice. Biol Pharm Bull 29(3): 585-587.

10. Fukushima M. et al. (2006). Effect of corosolic acid on postchallenge plasma glucose levels. Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, 1-5-4, Minatojimaminamimachi, Chuo-ku, Kobe, Japan.

11. Liu L. et al. (2001). An Extract of Lagerstroemia speciosa L. Has Insulin-Like Glucose Uptake-Stimulatory and Adipoctype Differentiation-Inhibitory Activities in 3T3-L1 Cells. J of Nutr. 131: 2242-47.

12. Hong H, Maeng W (2004). Effects of malted barley extract and banaba extract on blood glucose levels in genetically diabetic mice. J Med Food. 7(4): 487-90.

13. Gholap S, Kar A. Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Pharmazie 2003;58(6):413-415.

14. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002;81(1):81-100.

15. Jiang H. [Advances in the study on hypoglycemic constituents of Gymnema sylvestre (Retz.) Schult]. Zhong Yao Cai 2003;26(4):305-307.

16. Kamei K, Takano R, Miyasaka A, et al. Amino acid sequence of sweet-taste-suppressing peptide (gurmarin) from the leaves of Gymnema sylvestre. J Biochem 1992;111:109-112.

17. Khare AK, Tondon RN, Tewari JP. Hypoglycaemic activity of an indigenous drug (Gymnema sylvestre, "Gurmar") in normal and diabetic persons. Indian J Physiol Pharm 1983;27:257-258.

18. Kothe A, Uppal R. Antidiabetic effects of Gymnema sylvestre in NIDDM - a short study. Indian J Homeopath Med 1997;32(1-2):61-62, 66.

19. Lawless HT. Evidence for neural inhibition in bittersweet taste mixtures. J Comp Physiol Psychol 1979;93(3):538-547.

20. Meiselman HL, Halperin BP. Human judgments of Gymnema sylvestre and sucrose mixtures. Physiol Behav 1970;5(8):945-948.

21. Meiselman HL, Halpern BP. Effects of Gymnema sylvestre on complex tastes elicited by amino acids and sucrose. Physiol Behav 1970;5(12):1379-1384.

22. Min BC, Sakamoto K. Influence of sweet suppressing agent on gustatory brain evoked potentials generated by taste stimuli. Appl Human Sci 1998;17(1):9-17.

23. Murakami N, Murakami T, Kadoya M, et al. New hypoglycemic constituents in "gymnemic acid" from Gymnema sylvestre. Chem Pharm Bull 1996;44(2):469-471.

24. Porchezhian E, Dobriyal RM. An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents. Pharmazie 2003;58(1):5-12.

25. Narayanan et al (1987), Pinitol- A new anti-diabetic compound from the leaves of Bougainvillaea, Current Science, Vol 56, No 33, pp139-141.

26. Steenge GR, Simpson EJ and Greenhaff PL. Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. J Appl Physiol 2000;89: 1165-1171.

27. Haugland RB and Chang DT. Insulin effect on creatine transport in skelatal muscle (38464). Proc Soc Exp Biol Med 1975;148: 1-4.

28. Holman GD and Kasuga M. From receptor to transporter: insulin signaling to glucose transport. Diabetologia 1997;40: 991-1003.

29. White MF. The insulin signaling system and the IRS proteins. Diabetologia 1997;40 Suppl 2: S2-17.

30. Bates SH, Jones RB and Bailey CJ. Insulin-like effect of pinitol. Br J Pharmacol 2000;130: 1944-1948.

31. M. GREENWOOD, R.B. KREIDER, C. RASMUSSEN, A.L. ALMADA, AND C.P. EARNEST (2001) D-PINITOL AUGMENTS WHOLE BODY CREATINE RETENTION IN MAN. JEP: 4(4): 41-47.

32. Dale G, et al. Fitness, unfitness, and phosphate. British Medical Journal 1987; 294:939)

33. Kreider RB, et al. Effects of phosphate loading on oxygen uptake, ventilatory anaerobic threshold and in performance. Med Sci Sports Exer 1990; 22:250-255

34. Miller GW, et al. Effects of phosphate loading on anaerobic threshold. Med Sci Sports Exer 1991; 23:S35

35. Farber M et al. Effect of decreased oxygen affininty of hemoglobin on work performance in healthy humans. J Lab Clin med 1984; 104:166-175

36. Cade R, et al. Effects of phosphate loading on 2,3-diphosphoglycerate and maximal oxygen uptake. Med Sci Sports Exer 1984; 16:263-268

37. Stewart I, McNaughton L. Phosphate loading and effects of VO2 Max in trained cyclists. Res Quart 1990; 61:80-84

38. Chasiotis D. Role of cyclic AMP and inorganic phosphate in the regulation of glycogenolysis during exercise. Med Sci Sports Exer 1988; 20:545-550

39. Kreider RB, et al. Effects of phosphate loading on metabolic and myocardial responses to maximal and endurance exercise. Int J Sports Nutr 1992; 2:20-47

40. G. Shoba, D. Joy, T. Joseph, M. Majeed, R. Rajendran and P.S. Srinivas Influence Of Piperine On The Pharmacokinetics Of Curcumin In Animals And Human Volunteers. Planta Med. (1998) 64(4):353-356.

41. Vladimir Badmaev, M.D., Ph.D., Muhammed Majeed, Ph.D. and Edward P. Norkus Ph.D. Piperine, An Alkaloid Derived From Black Pepper, Increases Serum Response Of Beta-Carotene During 14-Days Of Oral Beta-Carotene Supplementation. Nutrition Research (1999) 19(3) 381-388.

42. Vladimir Badmaev, M.D., Ph.D., Muhammed Majeed, Ph.D., and Lakshmi Prakash, Ph.D. Piperine Derived From Black Pepper Increases The Plasma Levels Of Coenzyme Q10 Following Oral Supplementation. J. Nutr. Biochem. (2000) 11: 109-113.

43. Tallon MJ1 and Child R2. Kre-alkalyn® supplementation has no beneficial effect on creatine-to-creatinine conversion rates. 1University of Northumbria, Sport Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne, United Kingdom.2Department of Life Sciences, Kingston University, Penrhyn Rd, Kingston-upon-Thames, United Kingdom.

100% Casein (2 lbs.) By: Optimum Nutrition

100% Casein Protein: Slow Digestive Protein

Sometimes slower is better - especially when it comes to the rate of protein digestion. While rapid protein absorption is desirable immediately before or after exercise, delayed release is probably more beneficial throughout the remainder of the day.

Casein proteins are pH sensitive and gel in the acidic environment of the stomach. As a result, it can take more than twice as long for caseins to be broken-down into their amino acid subcomponents than whey and other proteins. Because of these unique "time-released" qualities, caseins are aptly described as being anti-catabolic, or muscle-protecting, proteins.

Animal PM (30 packs) By: Universal Nutrition

Animal PM: Rest, Recovery, Grow!

Rest and recovery... R&R. Yeah, we all need it to recuperate; to re-energize; to heal, the mind and the body. Problem is, too many of us see R&R as a luxury. How many of us have skipped vacations and time away from our jobs? How many of us stay at work, running on that neverending treadmill, day after day? Good ol’ R&R is perhaps the single most overlooked and least considered element of the mass building equation. But without it, you’re cooked. Serious training leaves you depleted. As we’ve all come to understand, you’re only as good as you can recover. Nutrition plays a critical role in accelerating healing, sure. But with the crushing stresses of heavy iron and the toxic environment that surrounds us in this crazy world, eating and supplementing right only goes so far. So what are you missing? Easy… Sleep.

If you can’t sleep properly and maximize the recuperation opportunities that come with your down time, you’ll never build the physique you desire. Period. You can train like a maniac, but the growth you seek happens outside the gym. Sleep time, put quite simply, equals growth time. With the busiest of schedules strained by work, family, training and commuting—the first thing to get cast to the side is adequate sleep. And without adequate R&R, you won’t reach your full potential.

Few of us reside in a perfect world, living a utopian existence simply predicated on optimizing our growth as bodybuilders. Our resources, be they monetary or time-related, are finite. For the busiest among us, we must manage our time to in all things get the best bang for our hard-earned buck. This is the case when it comes to muscle recovery. If all we can manage to allot for is six hours of sleep, bet your ass it needs to be the best six hours humanly possible. If quantity can’t always be within grasp, our quest for quality must take on even greater significance.

It was in the pursuit for optimizing rest to promote maximum recovery that the hard training fellas in Animal R&D decided to push the envelope, searching for any void in what is the most hardcore and comprehensive line in the game. What did they come up with? Only the most complete, ideal nighttime recovery supplement, something to lend that elusive edge to the most serious brothers in the game—those that regularly toe that fine line between training intensity and insanity. For them, there is Animal PM.

Benefits:

Sleep Enhancers
Relaxation herbs
Recovery agents
Immune support
GH boosters
EAA

Animal PM is a complete and comprehensive supplementation for the serious bodybuilder and only the serious bodybuilder. A single pack of Animal PM delivers a combination of ingredients that support growth hormone (GH), promote immune function, recovery agents, anabolic aminos and sleep and relaxation promoters.* Animal PM helps you get the most out of your sleep and by doing so, helps your body make the most out of repairing and growing.*

Animal PM´s sleep recovery formula starts with three whole grams of hGH (growth hormone) promoters designed to support the release of this ultra-anabolic hormone during slumber.* With GABA and alpha-GPC as well as "growth" output stimulating aminos arginine AKG, ornithine and L-tryptophan, Animal PM is a natural GH-production matrix that does its regenerative and muscle building work while your body is in a state of rest.*

The "Immune & Recovery Complex" is a blend of free form amino acids and prized patented compounds that help support heightened anabolism, promote protein synthesis and provide support to immune function, as the hazards of hard training and life in the real world leave your immune system and central nervous system under a state of constant attack.*

The "Immune & Recovery Complex" is bolstered even further by the kind of cutting-edge, patented ingredients you've come to expect from Animal.* Two such ingredients found in Animal PM are Humanofort and Immunolin. Humanofort is an embryonic peptide matrix which promotes myriad growth factors elementally responsible for new tissue growth such as IGF-1 and IGF-2.* Immunolin, on the other hand, is an immunoglobulin bovine extract rich in highly coveted growth factors.* These two premium compounds serve to "supercharge" the Animal PM formula.*

Finally, tying it all together and helping to completely differentiate Animal PM from any other generic recovery or sleep or relaxation product on the market, is the wicked "Sleep & Relaxation Complex".* This complex is designed to put you at ease and help support deep and restful sleep while the anabolic growth factors of the previous two complexes do their vital restorative work.* By natural, Animal PM facilitates a state of heightened relaxation priming you for reinvigorating anabolic sleep.*

Animal PM also delivers a blend of time-tested natural elements like valerian root, chamomile and hops. These three are then fortified with L-dopa (from mucuna pruriens) and L-theanine. These ingredients are further supported by the acclaimed mineral combo of zinc and magnesium.* Designed to not only contribute to more sound sleep but also to potentially promote anabolic hormone production in those mineral deficient.*

Animal PM is the most complete sleep & recovery product on the market, and the only one tailored specifically to the unique needs of balls-to-the-wall training bodybuilders. It’s not a relaxation product. It’s not a sleep aid. It’s not an anti-catabolic supplement. It’s not a GH booster. It’s not an immune support supplement. It’s not a recovery product. It’s all of these products, efficaciously dosed and wrapped up into one convenient, pre-dosed pack. It’s complete, serious sleep support for the dedicated iron athlete. Think of Animal PM as nothing short of a little R&R in a can.

Orange OxiMega Fish & Green Formula (1+ 1 Units) By: Controlled Labs

Orange OxiMega: Fish & Greens Formula!

Many people don’t realize the crucial effects that overall health supplements can play on their training. Without the essential nutrients your body needs to survive and flourish, it cannot build a strong foundation that is so crucial to lean mass gains. Orange OxiMega™ was designed to help you establish a strong, healthful, foundation on which to base your training, diet and supplementation. Coupled together with Orange TRIad™, you will have all of your overall health requirements exceeded including omegas, vitamins, minerals, fruit, vegetables, digestive support, immune support, joint support, and cardiovascular support.

Orange OxiMega™ is comprised of two products in every box. The first is a very high potency Nordic fish oil product that is 60% DHA/EPA. This is an extremely high level which allows for the overall consumption of less fat and cholesterol from your omega intake. Not only are these Nordic fish oil softgels a nutritional masterpiece, but they are enteric coated and citrus flavored so they smell/taste very good and you will not get any regurgitation (fish oil burps) that is common with cheaper more crude fish oil formulations. Our Nordic fish oil is also free from all contaminants and is molecularly protected with the inclusion of vitamin E so you can be assured of the utmost quality.

The second component of Orange OxiMega™ is a true sports greens product, which is the first of its kind. This is no ordinary greens product; it has additional complexes geared towards real athletes. The “Cardiovascular Complex” is full of nitrate donor vegetables, including a potent dose of red beet root, which have been shown to increase endurance, nitric oxide levels and cardiovascular health in exercising humans in a clinical setting. The key to these vegetables are the nitrates that are found in them and illicit this effect when they come in contact with the human tongue and GI tract. The enzyme, probiotic and anti-oxidant blends will help the body absorb and utilize the highest level of nutrients from your diet and supplementation for maximum results. Not only is this greens formulation healthful, but it tastes delicious too with its 100% naturally flavored spearmint without the use of any artificial sweeteners, flavors or colors (the product will mix a dark green/brown color due to the high level of red beet root in the formula).

120 Citrus Flavored Enteric Coated Softgels

Key Attributes:

Extremely High Potency EPA/DHA
Enteric Coated and Citrus Flavor (No Fish Burps!)
Free From Heavy Metals and Other Toxins
Vitamin E Fortified To Protect the Fish Oil
100% Nordic Fish Oils

318 Grams (0.70 Pounds) Spearmint Flavor

Key Attributes:

Great Spearmint Flavor
Natural Nitrate Donor Complex for Cardiovascular Health
NO Artificial Sweeteners, Flavors or Colors
Added Enzymes & Probiotics for Maximum Absorption
High in Natural Anti-Oxidants for Enhanced Performance

Establish a STRONG foundation for maximum gains in the GYM and in LIFE with Orange OxiMega™!

Orange OxiMega (120 Softgels) By: Controlled Labs

Orange OxiMega: Enteric Coated Fish Oil

Key Attributes:

Extremely High Potency EPA/DHA
Enteric Coated and Citrus Flavor (No Fish Burps!)
Free From Heavy Metals and Other Toxins
Vitamin E Fortified To Protect the Fish Oil
100% Nordic Fish Oils

Orange OxiMega™ is a very high potency Nordic fish oil product that is 60% DHA/EPA. This is an extremely high level which allows for the overall consumption of less fat and cholesterol from your omega intake. Not only are these Nordic fish oil softgels a nutritional masterpiece, but they are enteric coated and citrus flavored so they smell/taste very good and you will not get any regurgitation (fish oil burps) that is common with cheaper more crude fish oil formulations. Our Nordic fish oil is also free from all contaminants and is molecularly protected with the inclusion of vitamin E so you can be assured of the utmost quality.

Establish a STRONG foundation for maximum gains in the GYM and in LIFE with Orange OxiMega™!

D-aspartic Acid (DAA) (80 grams) By: NutraPlanet

NutraPlanet D-Aspartic Acid (DAA)

Human studies on men show a drastic increase in testosterone by 33% by supplementing D-aspartic Acid. NutraPlanet now offers buk DAA powder in 80 gram containers!

More information coming soon.

Lean Body MRP Tubs (2.47 lbs) By: Labrada

LEAN BODY® JUG: Meal Replacement Shake!

Lean Body® Meal Replacement Shakes are NOW in a Jug! Lean Body® still has the same great taste as the packets and provides maximum support for muscle growth gains while minimizing fat storage in hard-training athletes. Each serving contains 35 grams of LeanPro®, our exclusive blend of the highest quality proteins. It also provides, 24 essential vitamins and minerals and only 5 grams of sugar. Lean Body® is now packed with 7 grams of fiber, yet contains no maltodextrin, artificial colors, preservatives, or Trans Fat. Note: 16 Servings per jug.

labradanpmarch2010

Lean Body MRP Tubs (2.47 lbs) By: Labrada

labradanpmarch2010

Lean Body MRP Tubs (2.47 lbs) By: Labrada

labradanpmarch2010

NutraPlanetNew Products

Hard FX (112 caps) By: Anabolic Xtreme

Hard FX: Hardcore Testosterone Activator!

Applied Performance Stack + FREE AN Gym Bag! By: Applied Nutriceuticals

For a LIMITED TIME ONLY, Buy Together and SAVE BIG BUCKS!!!

Each Stack Includes the Following:

1X Drive (110 caps)

1X RPM (110 caps)

1X NeoVar JumpStart (110 caps)

DRIVE™ by Applied Nutriceuticals™

RPM: Radical Performance Maximizer!

Neovar JumpStart (110 caps): Next Generation Creatine for Maximum Cellular Recovery!

100% Casein (2 lbs.) By: Optimum Nutrition

100% Casein Protein: Slow Digestive Protein

Animal PM (30 packs) By: Universal Nutrition

Animal PM: Rest, Recovery, Grow!

Orange OxiMega Fish & Green Formula (1+ 1 Units) By: Controlled Labs

Orange OxiMega: Fish & Greens Formula!

Orange OxiMega (120 Softgels) By: Controlled Labs

Orange OxiMega: Enteric Coated Fish Oil

D-aspartic Acid (DAA) (80 grams) By: NutraPlanet

Lean Body MRP Tubs (2.47 lbs) By: Labrada

Lean Body MRP Tubs (2.47 lbs) By: Labrada

Lean Body MRP Tubs (2.47 lbs) By: Labrada