• Currently 4.2267/5
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Rating: 4.2267/5 (75 votes cast) | View All 13 Reviews

Alphamine (252 Grams)

Manufactured By: PES


Price: $89.99$36.99

Availability: On Order


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Shipping Methods
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PES' NEW Alphamine (New Formula):

Innovative & Powerful Thermogenic Powder!

After two years of undeniable feedback from Alpha-T2, we sat down to begin our research onto an even greater, more innovative, more powerful fat burner…

We realized all the fat burners on the market hold MAJOR flaws…we set out to create a solution. In search for our goal, we stumbled across the most effective and innovative formulation that has EVER been introduced......And with that said, PES' NEW Alphamine was born!

ALPHAMINE is a revolutionary fat loss product with no other comparison! Here are just a few reasons why....

Unmatched Formula

Alphamine delivers a scientific formula geared towards ultimate physique enhancement. New stimulants. Superior Extracts. Ultra Thermogenesis. Strong Appetite Suppression. Lean Mass Preservation. Extreme Hardening Agents.

This powdered product delivers ingredients faster than any capsule on the market while allowing the highest degree of variable dosing. Two small scoops with 10oz of water tastes so good you'll want to drink it for enjoyment! Need a little more or a little less? No worries...with a powdered formula you are in FULL CONTROL of dosing unlike a capsule. Find the perfect dose for YOU.

Burn Fat NOT Muscle

Until ALPHAMINE, no products are designed to selectively burn FAT while preserving muscle mass. Crazy…right? So many products based on energy and weight loss…but not FAT loss.

Male or female, no matter how much fat you want to drop nobody wants to lose their precious muscle mass. Hard dieting, heavy stimulants, and extreme cardio all are begging to break down your muscle tissue for energy. Shift the focus to FAT loss.

Alphamine takes physique enhancement a step further. Not only is this formula designed to shed fat and preserve muscle, we have included a potent muscle hardening agent in every serving. A flabby stomach is annoying enough as it is…the last thing you need are flabby muscles! Demand more than just fat loss…demand full physique transformation.

Allow us to present to you the new definition of a fat burner…

Unmatched Formula…The All-Inclusive Physique Transformer

Alphamine delivers ingredients acting both independently and synergistically in a formula that takes fat loss to the next level…no…this is beyond the next level. This is an entirely new playing field!

This potent thermogenic powder is built for a fast acting custom serving for every user. As a powdered thermogenic, each and every user can fully customize their serving size and frequency if they choose. No more being stuck with only 1 or 2 capsules…full customizable dosing anytime, anywhere. Find YOUR sweet spot.

Alphamine mixes quick and easy with a spoon and tastes like something you’d only drink on your cheat days…no medicine mouth here! Two small scoops with 10 oz. of water and you can be on your way…

New Innovative Stimulant System

Alphamine is formulated around stimulants that make sense. Stimulants designed to burn fat, give you a great sense of wellbeing and energy, and suppress your appetite all day. Kevin, one of our beta-testers said "Alphamine feels like Alpha-T2 and ephedrine stacked!"

Revolutionary Hardening Agents

When we designed Alphamine we asked ourselves how can a fat burner show even greater changes in the mirror...and then we found it. By combining extreme hardening agents into a fat loss formula users feel and see changes in their physique faster than ever. Why limit to just losing fat when you can make your lean mass leaner, harder, and denser than ever? As the fat sheds off; your muscles truly show through!

Lean Body Mass Preervation System

Alas...the ultimate problem with fat burners today. Every other fat burner just cares about losing weight...we focus Alphamine on FAT loss. Don't lose muscle...preserve it! An innovative touch of muscle preservation in every serving. This formula is designed for the hardcore...

Alphamine is Like Stacking THREE Different Products!

Alphamine will launch in two flavors - Fruit Punch and Raspberry Lemonade. No...not the cough medicine versions...the fruit drink versions.

Extreme Thermogenic. Selective Synergistic Stimulants. Novel Extracts.,,,SUPERIOR Fat Igniting Technology!

Alphamine uses novel extracts and potent stimulants to take thermogenesis to a whole new level. For two years users have raved about the strong thermogenic effect of Alpha-T2. Welcome to the future of thermogenesis...Alphamine takes it into overdrive.

Beta-Agonist Blend:

Beta-agonists have shined for decades for a reason…they work. PES is staying on the forefront of supplement science with the novel beta-agonists in Alphamine.


Back in the day yohimbine was the new kid on the block…since then science has prevailed and discovered newer, cleaner, more selective forms of yohimbine such as rauwolscine. But it CAN get better. Using a unique extract, PES has gone even further after experimenting with numerous specialized extracts to develop SA2-A™, the cleanest extract to date. The Pausinystalia bark holds as many as a dozen alkaloid molecules that have gone unnoticed…we knew there was more to take advantage of.

Oleuropein from Olive Leaf

One of the most underrated ingredients today, oleuropein extracted from olive leaves holds numerous properties.  Already this past year olive leaf extracts have been the focus of new research and new discoveries...PES staying on the forefront once again..

Eucommia Ulmoides – 98% Chlorogenic Acid Extract

Chlorogenic acid, commonly found in green coffee beans, is becoming popular for its strong scientific backing…but we needed something more pure. Instead we went to Eucommia, an herb with high content of chlorogenic acid.


We could write an entire article on the importance and biological functions of choline in the body, but we will strictly focus on why it found its way into Alphamine. First and foremost, when choline was added to this mixture the overall feel of each serving changed significantly. The formula became much smoother and longer lasting with the addition of choline.

Lean & Hard:

Alpha-Hydroxy-Isocaproic Acid (Leucic Acid)

Leucic Acid (HICA) is a metabolite of the well-known branched chain amino acid Leucine. BCAA users know that Leucine is the star amino acid. Its properties have been heavily researched and proven time and time again. The only drawback with Leucine is the high amount needed…enter Leucic Acid.

Enjoy The Revolution….More To Come From PES!

Alphamine References:

Berlan M, Galitzky J, Riviere D, et al. Plasma catecholamine levels and lipid mobilization induced by yohimbine in obese and non-obese women. Int J Obes. 1991 May;15(5):305-315
Galitzky J, Taouis M, Berlan M, et al. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. Eur J Clin Invest. 1988 Dec;18(6):587-594
Flechtner-Mors M, Jenkinson CP, Alt A, et al. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. J Pharmacol Exp Ther. 2002 Apr;301(1):229-233
Sax L. Yohimbine does not affect fat distribution in men. Int J Obes. 1991 Sep;15(9):561-565
Kucio C, Jonderko K, Piskorska D. Does yohimbine act as a slimming drug? Isr J Med Sci. 1991 Oct;27(10):550-556
Berlin I, Stalla-Bourdillon A, Thuillier Y, et al. Lack of efficacy of yohimbine in the treatment of obesity. J Pharmacol. 1986 Jul-Sep;17(3):343-347
Zahorska-Markiewicz B, Kucio C, et al. Adrenergic control of lipolysis and metabolic responses in obesity. Horm Metab Res. 1986 Oct;18(10):693-697
Perry BD, U’Prichard DC. [3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol. 1981 Dec 17;76(4):461-464
Berlan M, Le Verge R, Galitzky J, et al. Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine. Br J Pharmacol. 1993 Apr;108(4):927-932
Chang KC, Lim JK and Park CW (1986) Synthesis of higenamine and its cardiovascular effects in rabbit: Evidence for b-adrenoceptor agonist. Kor J Pharmacol 22:96 –104
A study on the mechanism of the yang-tonic effect of higenamine. Xiang Rong. Yi Ningyu. Xia Zongqin. PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA. 1994-06
The Chinese Journal of Clinical Pharmacology, 2007-04. Tolerability of higenamine hydrochloride in healthy volunteers. Yan-rong, Fang, Ri-yi,Yan, OUYANG, Meng, Hong-li.
Eur J Nucl Med. 1983;8(6):233-6. Measurement of effects of the Chinese herbal medicine higenamine on left ventricular function using a cardiac probe. Liu XJ, Wagner HN Jr, Tao S. Planta Med 2009; 75(13): 1393-1399. β2-Adrenoceptor-Mediated Tracheal Relaxation Induced by Higenamine from Nandina domestica Thunberg Muneo Tsukiyama, Takuro Ueki, Yoichi Yasuda, Hiroko Kikuchi, Tatsuhiro Akaishi, Hidenobu Okumura, Kazuho Abe.
CHINESE PHARMACOLOGICAL BULLETIN 1995-02. The pharmacologic action of higenamine on beta-adrenergic receptors in heart of mice. XIANG Rong; XU Jiang-Tao; YI Nin-Yu; XIA Zhong-Qin
Acta Pharmacol Sin 2008 Oct; 29 (10): 1187–1194. Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist. Gang BAI, Yang YANG, Qian SHI, Ze LIU, Qi ZHANG, Yuan-yuan ZHU
An Experimental Study on Adrenergic Effect of Higenamine in Rabbit Cardiovascular System. Nam Su Kim,Chang Yee Hong,Chan Woong Pak,Jung Kyoo Lim. Korean Circ J 1986;16:1-18
Diepvens K, Westerterp KR, Westerterp-Plantenga MS. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R77-85
Bracco D, Ferrarra JM, Arnaud MJ, et al. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. Am J Physiol. 1995 Oct;269(4 Pt 1):E671-E678
Dullo AG, Geissler CA, Horton T, et al. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr. 1989 Jan;49(1):44-50
Acheson KJ, Gremaud G, Meirim I, et al. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr. 2004 Jan;79(1):40-46
Kaplan GB, Greenblatt DJ, Ehrenberg BL, et al. Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol. 1997 Aug;37(8):693-703
Smith A. Effects of caffeine on human behavior. Food Chem Toxicol. 2002 Sep;40(9):1243-1255
Robertson D, Frolich JC, Carr RK, et al. Effects of caffeine on plasma renin activity, catecholamines and blood pressure. N Engl J Med. 1978 Jan 26;298(4):181-186
Oleuropein, a Phenolic Compound in Extra Virgin Olive Oil, Increases Uncoupling Protein 1 Content in Brown Adipose Tissue and Enhances Noradrenaline and Adrenaline Secretions in Rats. Yuriko Oi-KANO, Teruo KAWADA, Tatsuo WATANABE, Fumihiro KOYAMA, Kenichi WATANABE, Reijirou SENBONGI, Kazuo IWAI. Journal of Nutritional Science and Vitaminology Vol. 54 (2008) No. 5 P 363-370
Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats. Poudyal H, Campbell F, Brown L. J Nutr. 2010 May;140(5):946-53. Epub 2010 Mar 24.
Effect of freeze dried extract of Olea europaea on the pituitary-thyroid axis in rats. Al-Qarawi AA, Al-Damegh MA, ElMougy SA. Phytother Res. 2002 May;16(3):286-7.
Effects of Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food intake, and body weight. Horii Y, Tanida M, Shen J, Hirata T, Kawamura N, Wada A, Nagai K. Neurosci Lett. 2010 Aug 2;479(3):181-6. Epub 2010 May 16.
Chlorogenic Acid and Synthetic Chlorogenic Acid Derivatives:  Novel Inhibitors of Hepatic Glucose-6-phosphate Translocase. Horst Hemmerle, Hans-Joerg Burger, Peter Below, Gerrit Schubert, Robert Rippel, Peter W. Schindler, Erich Paulus, and Andreas W. Herling. J. Med. Chem., 1997, 40 (2), pp 137–145
Role of Glucose-6 Phosphatase, Glucokinase, and Glucose-6 Phosphate in Liver Insulin Resistance and Its Correction by Metformin.    Carol Minassian, Sandrine Tarpin,Gilles Mithieux. Biochemical Pharmacology Volume 55, Issue 8, 15 April 1998, Pages 1213–1219.
The Effect of Chlorogenic Acid Enriched Coffee on Glucose Absorption in Healthy Volunteers and Its Effect on Body Mass When Used Long-term in Overweight and Obese People. Thom, E. The Journal of International Medical Research, Volume 35, Number 6, November 2007 , pp. 900-908(9).
Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans.  Margreet R. Olthof, Peter C. H. Hollman, and Martijn B. Katan. J. Nutr. January 1, 2001 vol. 131 no. 1 66-71
Park JB. N-coumaroyldopamine and N-caffeoyldopamine increase cAMP via beta 2-adrenoceptors in myelocytic U937 cells. FASEB J. 2005 Apr;19(6):497-502
Kline WO, Panaro FJ, Yang H, et al. Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol. J Apply Physiol. 2007 Feb;102(2):740-747
Goncalves DA, Lira EC, Baviera AM, et al. Mechanisms involved in 3,5-cyclic adenosine monophosphate-mediated inhibition of ubiquitin-proteasome system in skeletal muscle. Endocrinology. 2009 Dec;150(12):5395-53404
Kunkel SD, Suneja M, Ebert SM, et al. mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. Cell Metab. 2011 Jun 8;13(6):627-638
Lee NK & MacLean HE. Polyamines, androgens, and skeletal muscle hypertrophy. J Cell Physiol. 2011 Jun;226(6):1453-1460
Anthony J. C., Anthony T. G., Kimball S. R., Vary T. C., Jefferson L. S. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J. Nutr. 2000;130:139-145
Tischler M. E., Desautels M., Goldberg A. L. Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?. J. Biol. Chem. 1982;257:1613-1621
Kimball S. R., Shantz L. M., Horetsky R. L., Jefferson L. S. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability fo eIF4E and phosphorylation of ribosomal protein S6. J. Biol. Chem. 1999;274:11647-1
Buse M. G., Weigand D. A. Studies concerning the specificity of the effect of leucine on the turnover of proteins in muscles of control and diabetic rats. Biochim. Biophys. Acta 1977;475:81-89
The effect of choline supplementation on the level of plasma free fatty acids and beta-hydroxybutyrate during a session of prolonged exercise.  Qolizadeh, M. R.; Ebrahim, K.; Rahbar, B.; Karami, E.; Rostamkhany, H.; Musavi, S. H. Annals of Biological Research 2011 Vol. 2 No. 6 pp. 253-260

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease or illness.

Banned Countries

This item is banned in the following countries: Sweden [Higenamine HCl], Australia [yohimbe]

Customer Reviews for Alphamine (252 Grams) by PES

Write a review and share your thoughts with other customers.

View All 13 Reviews For Alphamine (252 Grams)

  • Currently 5/5
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Perfect Thermo By: matt

Review posted on: 2012-11-24 12:34:48 -0500

Taste is outstanding. I am usually stimulant sensitive but this product has just the right amount to keep me going without overpowering side effects. Also seemed to sweat more on it, Which is a good thing in this case!

  • Currently 5/5
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Really subtle and powerful By: Adam

Review posted on: 2012-11-02 16:33:05 -0400

Tried 2 scoops at once, and have to admit at first I was really disappointed...but then, it hit. My sweating was going crazy sand the energy was tremendous. Another great product from PES. Well done folks

  • Currently 5/5
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Alphamine a great fat burner By: Eric

Review posted on: 2013-03-24 23:55:16 -0400

Taste: First off the taste of this stuff is great, sweet enough but not over powering. I rather enjoyed my morning serving of 10oz two scoops because how great it tasted! Mixability: mixed great no issues lumps clumps anything. it mixed rather quickly in about 15 seconds. Appetite : it slightly lowered my appetite but nothing crazy which for me is important. Side effects: slight stomic discomfort, and i would have to use the restroom after taking my first dose ( 2 scoops). When i started to take 2 scoops it was my 3rd day. and it was to much to bare. so for the first 5-6 days i just took 1 scoop twice daily, than went to 3 scoops, which took away the discomfort. It just took me slightly longer to become used to it. on a scare from 1-10, 10 being unbearable it was only about a 5 until i got used to it than became a 3-4 depending. Stim: very slight stim effect, which i enjoyed because im not a big stim guy, so when i have 6am clients it was nice way to get me moving without that rush were you can not sit still. So all in all i lost 2 pounds and 1.5% body fat (9 point caliper) while still increasing my strength in 4 weeks. I am very happy with the results and have 2 more bottles so an 8 week run will be a must for fantastic results! I recommend this product to anyone who wants a great fat burner, that has slight preworkout effects.

  • Currently 5/5
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In Review: Alphamine By: David

Review posted on: 2013-03-21 23:24:08 -0400

Of all the possible preworkouts, fat burner drinks, and any other supplement that has any flavoring in it... Alphamine is easily the best tasting out of all of them! Cracking open a new tub will instantly fill your nostrils with a sweet aroma... and it tastes even better than it smells! When I first received Alphamine I tried dosing it in just about every way possible to see what worked best for me. I assessed my tolerance to it by following the directions on the side of the tub. I was surprised to see that the label said there were 84 servings in there yet the tub seemed so small. Once I opened it up I realized why... the scooper is tiny! Took 1 scoop with 6 oz. of water for the first 2 days before bumping up my dose. As I've already said, the taste was AMAZING and all I wanted to do was mix the entire tub into one of those huge orange coolers you see coaches getting dumped on with and just drink it all day long! After the first two days I messed around with the dosage and timing: 1 scoop prior to breakfast and 1 scoops prior to dinner. 2 scoops prior to breakfast only. 2 scoops prior to dinner early. 1 scoop mixed in with preworkout. 2 scoops mixed in with preworkout. 2 scoops before breakfast and 1 scoop before dinner. 2 scoops preworkout and 1 scoop before dinner. Multiple combintations of dosings with endless possibilities while all arriving to the same fantastic effects of the fat burning potential found within those highly concentrated ingredients! Within the first few days of trying Alphamine I knew I was in for a different fat burner. I usually don't respond well to thermogenics and usually roll my eyes when a product claims to be "the BEST thermogenic on the market." Alphamine proved me wrong. The thermogenic effects come on fast and last for a good 6-8 hours. I took this over winter and I actually found myself having to strip layers of clothes off when indoors because I would be getting too hot! During cardio I noticed that I would sweat MORE than usual and that I would begin sweating more towards the beginning of my workout rather than the middle. I even found myself sweating more often during weight lifting workouts and I usually never sweat doing that. Alphamine also provides you with a great energy kick. I work night shift and I would take Alphamine prior to heading into work, and about the time I would eat dinner is when I'd need another 'pick-me-up' and Alphamine helped me make it through my 12 hour shift without the extra use of other caffeine drinks or energy products. I've yet to take a product that suppresses my appetite... until I ran into Alphamine. When taken prior to my shift I found myself not just snacking less between meals... but not snacking at all! Once the thermogenesis effect kicks in you know your appetite is shut down! You don't feel full... you just don't ever get that growling stomach sensation that you need to eat something. Alphamine also did a great job at helping me lean out slightly... even though my diet was not on point 24/7. The tub lasted me about a month and a half, and during this time I continued to gain strength in the gym, lost a few pounds, started seeing some new vascularity (not necessarily new growth, but simply due to the fact that I was decreasing my body fat % to the point that the muscles underneath my skin were pushing those veins to a visible view), and (especially when taken preworkout and pre-meal) I noticed that, almost similar to the effects of agmatine, my muscles became fuller, seemed to have more "pop" to them in the mirror (thanks to the leaning effects!), and felt more pumped/hard throughout the day. Alphamine was definitely a huge surprise hit with me and is something I will be looking to add into my aresenal of supplements in order to continue to make new gains and keep my biggest critic of myself happy: the mirror.

  • Currently 5/5
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A+ for Alphamine By: Peter

Review posted on: 2013-02-08 12:40:27 -0500

Love this product. Love the taste, the innovative formula, love the effects and feel of alphamine. This has been one of my favorite products released in the past year. I've used many tubs and it also works very well for those who do Intermittent Fasting. This will work best in a low insulin environment and the smooth energy will help during the fasting periods. I think it's a great value considering the ingredients and doses used. Alphamine is as good a fat burner as you're going to find. PES has really caught my attention with their innovation and effective formulas. I'm keeping a very close eye on future releases from this company especially with their Enhanced pre-workout on the way.

View All 13 Reviews »

Alphamine Supplement Facts

Serving Size: 1 Scoop (3g)
Servings per Container: 84

  Amount Per Serving % Daily Value

Alphamine FIT Matrix:

1577.5 mg **

Lean Performance System:
Choline Bitartrate, Alpha-Hydroxy-Isocaproic Acid, Eucommia Ulmoides Leaf
(98% Chlorogenic Acid), Olive Leaf (Standardized for Oleuropein)

Ergo-Thermogenic System:
Caffeine Anhydrous (125 mg), Higenamine HCl, Pausinystalia Yohimbe (Bark)
Extract (SA2-A™)
N-Coumaroyldopamine 10 mg **

* Percent Daily Values are based on a 2000 calorie diet.
** Percent Daily Values not established.

OTHER INGREDIENTS:  Citric Acid, Natural and Artificial Flavors, Silicon Dioxide, Sucralose, Acesulfame Potassium, Magnesium Stearate, Beet Juice Concentrate Powder.

Supplement Facts Fruit Punch flavor.

Alphamine Directions:

Begin drinking 1 scoop mixed with 4-5 oz water on an empty stomach 15-30 minutes before breakfast for the first two (2) days to assess tolerance. An additional 1 scoop may be taken 5-6 hours later. Once the above steps have been taken, an additional scoop may be added to the morning serving on day 3. DO NOT EXCEED 3 SCOOPS IN ANY 24 HOUR PERIOD. DO NOT USE PRODUCT FOR LONGER THAN 8 WEEKS FOLLOWED BY A SUBSEQUENT 4 WEEK BREAK. Consume at least 125 Fl. Oz. of liquid per day for men and 91 Fl. Oz. of liquid per day for women while taking this product. Under no circumstances should the initial dose be exceeded or the warnings on this bottle be ignored.

Alphamine WARNING:

DO NOT USE IN COMBINATION WITH CAFFEINE OR ANY STIMULANTS FROM OTHER SOURCES, INCLUDING BUT NOT LIMITED TO COFFEE, TEA, SODA, AND OTHER DIETARY SUPPLEMENTS OR MEDICATIONS. DO NOT USE UNDER EXTREME CONDITIONS OF HEAT, SLEEP DEPRIVATION OR DEHYDRATION. DO NOT COMBINE WITH ALCOHOL. This product is only intended to be consumed by healthy adults 18 years of age or older. Consult with your physician before using this product, especially if you are using any prescription or over the counter medication or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication. This product contains caffeine and should not be taken by individuals wishing to eliminate this ingredient from their diet. Discontinue use 2 weeks prior to surgery. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.