NutraPlanet's Yohimbine Caps: Buy 1 Get 1 FREE!!!
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Information courtesy of Par Deus
One of the major contributors to body weight homeostasis in the human body is the sympathetic nervous system, the principal components of which are the catecholamines (epinephrine and norepinephrine) and the andrenergic receptors. There are two types of adrenergic receptors, alpha and beta, as well as subtypes of each -- and depending on which are activated, lipolysis (breakdown of fat) can be either stimulated or inhibited.
The most well-known adrenoreceptors to bodybuilders are the beta receptors. These can be divided into subtypes 1, 2, and 3 -- and it is through these receptors that drugs such as the ephedrine/caffeine stack and Clenbuterol exert their effects. While Clenbuterol acts directly on beta 2 receptors, ephedrine exerts its effects indirectly by stimulating the release of norepinephrine (NE), the body's primary endogenous thermogenic hormone. Unlike Clenbuterol, NE is not selective in its binding. In addition to binding to the beta 2 receptor, it also binds to both alpha receptors, as well as the beta 1 and 3 receptors. It is in regards to its binding to the alpha 2 receptor that yohimbine comes into play.
Norepinephrine and Yohimbine
Ativation of the alpha 2 receptor inhibits the release of NE. Thus, by binding to this receptor, NE functions as its own negative feedback signal. In other words, it shuts off its own release. Obviously, this is not a good thing for fat loss. This is particularly true at rest (which, unless you are a marathon runner is 95% of your day) -- this is because alpha 2 receptors are activated at lower catecholamine levels than are the beta receptors (1). Thus, thermogenesis is basically always turned off. It is the differences in regional distribution of alpha 2 and the beta receptors that is responsible for the gender differences in bodyfat storage (2). Basically, females have a large number of alpha 2 receptors and few beta receptors in the gluteofemoral area (hips, thighs, and butt), while men have the same problem in the midsection. With exercise or the use of compounds such as the ephedrine/caffeine stack, catecholamine levels can be increased to a point where the alpha 2 induced inhibition of lipolysis is partially overcome (1). However, even then, the alpha 2 receptors ARE still acting to reduce lipolysis. Yohimbine is a selective alpha 2 antagonist (3) and can thus short circuit this feedback loop, maximizing NE levels, thus maximizing fat loss, particularly in these problem areas.
Blood Flow
A second, more indirect, mechanism by which Yohimbine can aid lipolysis via the adrenergic system is by increasing peripheral blood flow (4, 5). Adipose tissue is known to have rather poor vascularity. When triglycerides are broken down into free fatty acids and glycerol during lipolysis, they must also be transported away from the fat cell or they risk being reincorporated into adipose tissue. Beta receptor activation causes vasodilation, thus increasing blood flow, however, it does not increase enough to remove all of the free fatty acids released during lipolysis (6). Alpha 1 and 2 receptor activation, on the other hand, causes a decrease in blood flow (2, 7). Thus, antagonism of the alpha 2 receptor with yohimbine would be expected to increase blood flow, and thus increase the mobilization and disposal of these FFA's, further aiding fat loss.
Yohimbine vs. Yohimbe
Quite a bit of confusion seems to exist about the difference between Yohimbine and yohimbe. Yohimbine is the principal alkaloid from the herb P. yohimbe. However, there are 31 other yohimbane alkaloids that can be present in herbal yohimbe preparations. Some of these have different and unknown selectivities and potencies (and thus, effects) at the adrenergic receptors (8, 9) -- in addition, these preparations vary greatly from brand to brand and even from batch to batch, as no standardization for extraction exists. In fact, a recent investigation found that most over the counter preparations have little to no actual yohimbine (10). And, even in the more potent preparations, most people find a higher degree of undesirable effects with the herb vs. pure Yohimbine (due to the afore mentioned 31 other yohimbane alkaloids that can be present).
Dosing
Studies have concluded that the ideal dosing for Yohimbine is .2mg/kg (11) -- this would be 20mg for a 220lb person (0.09 mg/lb of body weight). Studies using smaller dosages have produced less favorable results. At this level, little to no side effects have been reported (Keep in mind, this is with Yohimbine HCl, not the yohimbe herb). Another thing to be considered when using yohimbine is that insulin completely blunts its lipolytic effects, thus it should ideally be used on a low-carb/ketogenic diet, or at the very least, first thing in the morning on an empty stomach, followed by moderate aerobic activity for an extended period.
Write a review and share your thoughts with other customers.
Best short term energy boost By: Thomas
Review posted on: Fri Mar 07 22:40:00 -0500 2008
I weigh 195lbs 6 caps of these about 30 mins prior to working out on an empty stomach are perfect. Definitely worth a try and at this price you can't go wrong..
try it By: anthony
Review posted on: Tue Nov 13 16:55:21 -0500 2007
no side effects great price but i didn't take it every day. It made my abs seem a little leaner with the same diet. i would only take it 2-3 times a week
I love Yohimbine By: Patrick
Review posted on: Tue Nov 13 16:55:18 -0500 2007
Simply put, this stuff is awesome! It burns fat,makes you horny, makes bigger erections and gives good PWO energy and is cost effective! Some users do experience heart palpetations and increased BP, but none of that happened to me. Most users report more side from Yohimbe and not Yohimbine.
i love Nutra Caps By: Ben
Review posted on: Tue Nov 13 16:55:09 -0500 2007
High quality and affordable. what more can i say.
i stacked np yohimbine caps, with green tea caps and caffine for a very cheap and effective cutting stack. worked like a champ with a clean diet and cardio.
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Directions:
As a dietary supplement consume 1-2 capsules daily or use as directed by a physician or licensed nutritionist. Begin using this product at 1/2 the suggested dose to assess tolerance.
WARNING:
Not for use by individuals under the age of 21 years of age. Consult a physician prior to use if you have any medical condition including but not limited to: strokes, high blood pressure, heart, liver, kidney or thyroid disease, diabetes, anemia, depression, anxiety, other psychiatric conditions, a family history of these or any other medical conditions, or if using any prescription, OTC, and/or other herbal medications.
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