NA-RALA (25 gm)

Na-RALA: The Next Generation Antioxidant

• 30% stronger than K-RALA and is a free-flowing powder
• 15g Na-RALA = 20g K-RALA
• 57g Na-RALA = 100 g K-RALA

In 2003, GeroNova launched the first stabilized R-lipoic acid (RLA) containing dietary ingredient into the nutraceutical market: K-RALA (Potassium RLA).

The pure potassium salt is unstable and had to be supported on silica and MCC after de-polymerization to make it suitable for tablets and capsules.

The additional processing raised the cost of an already expensive raw material (RLA), and could only be offered with a 40% active load.



Na-RALA: The Next Generation RALA



Bio-EnhancedTM Na-RALA is a 70% active R-lipoic acid powder is stable, extremely low (<2.0 %) in insoluble polymer and offers an innovative solution for capsules, tablets and powdered drink mixes.



Bio-EnhancedTM Na-RALA is completely water soluble.



Bio-EnhancedTM Na-RALA is significantly more bioavailable than R-lipoic acid (RLA).

· 1000mg (1gram) RLA reaches a maximum concentration (Cmax) of 1.1ug/ml in human plasma

· 100mg (0.1gram) Bio-Enhanced Na-RALA reaches a Cmax of 2.3ug/ml

· On a weight basis Bio-Enhanced Na-RALA reaches a Cmax 21 times higher than RLA.





Specifications:



Bio-EnhancedTM Na-RALA powder is an off-white to yellowish powder, with 70% active R-lipoic acid.



Bio-EnhancedTM Na-RALA powder is soluble in water. 1 g dissolves in 50 ml water at room temperature.



Bio-EnhancedTM Na-RALA powder melts at 240° ~ 250° C (with decomposition beginning at (~210° C).



Bio-EnhancedTM Na-RALA powder is free flowing, heat stable up to 85° C and ready for blending with excipients.





Advantages:



Increased stability:

Bio-EnhancedTM Na-RALA requires no refrigeration and has a shelf life of at least 3 years without polymerization. Solid R-Lipoic Acid is prone to quickly polymerize upon exposure to heat, light, and moisture.



Increased Solubility:

cleanly soluble in water, whereas RLA is poorly soluble and K-RALA can only be dispersed because of the insoluble excipients.



Reduced Solvent Residues:

due to the low melting point of the lipoic acid crystalline structure, there is a tendency for RLA to hold on to high amounts of cyclohexane, ethyl acetate or toluene.



The additional processing necessary to make Bio-EnhancedTM Na-RALA removes the residual solvents.





To deliver a 100 mg active dose of RLA required 250 mg K-RALA-40%

To deliver a 100 mg active dose of RLA requires 143 mg Na-RALA-70%

Certificate of Analysis

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Customer Reviews for NA-RALA (25 gm)

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Better than Gluco----- By: Robert

Review posted on: Tue Nov 13 16:55:06 -0500 2007

I try and buy all my supplements from NutraPlanet. If they don't carry it - I ask them to consider stocking it. You buy 200$ and you get it shipped free -- I always shoot for that. Their products always arrive promptly and on my last order they threw in a NutraPlanet Tshirt (nice Tshirt - thanks guys) If you only have cash for 5 things -- make this one of them. Its the foundation -- with ALCAR for mental acuity and antioxident overdrive. This is a phenomenol deal -- they dont even sell this stuff yet at vitamin cottage - where it would cost 10x more...