Adipose Annihilation (180 caps)

Adipose Annihilation: Relentlessly Annihilate Body Fat From Every Possible Angle!

Commercial fat burners come a dime a dozen.  Far too many hide cut-rate ingredients and lack of proven results behind flashy advertisements.  Bikini-clad supermodels make outrageous (or downright deceitful) claims on behalf of products they’ve never used, products that aren’t worth the bottle they’re packaged in.

Luckily, Adipose Annihilation is not your ordinary fat burner.

By employing clinically proven, full-strength ingredients in two unique proprietary blends, Adipose Annihilation lets you ignite your full fat burning potential.  Unlike “one trick pony” competitors that attempt to limit fat gain through a single mechanism, Adipose Annihilation’s DESTRUCTION COMPLEX ceases new fat formation as the SHRED COMPLEX lays waste to existing adipose stores.  You’ll literally annihilate fat from every possible angle!

If you’re hardcore, stack Adipose Annihilation with Recompadrol.  Throw in an aromatase inhibitor [1] and you can create a truly unparalleled body recomposition arsenal.  Even the most experienced dieter will stare slack-jawed in the mirror as they wake up each morning leaner and leaner than ever.

Synergy is the key to these remarkable results; Adipose Annihilation’s ingredients compliment one other to create “2 + 2 = 5” fat melting maximization.  Hydroxycitric Acid and Carnitine in the DESTRUCTION COMPLEX interact to mobilize and transport fat.  Then the SHRED COMPLEX takes over, as Fucoxanthin, Octopamine, Alpha Yohimbine, and Capsaicin combine to vanquish fat stores through PPARγ adrenoreceptor antagonism.  The β3 agonists improve nutrient uptake, shuttling, and overall partitioning.

This synergy continues with Recompadrol – ingredients like Berberine and Salacia Reticulata, two PPARγ antagonists/PPARα agonists, add fuel to the fat burning fire.  Moreover, Recompadrol’s Corosolic Acid blunts the body’s tendency to upregulate fat storing enzymes in periods of long-term PPARα agonism.  But that’s not it!  Berberine caused “11-HSD1, a key enzyme linked to visceral obesity and metabolic syndrome, decreased 0.63-fold” in a recent medical study [2]; with 11-HSD1 downregulated, cortisol control will no longer be a challenge.  Through the sheer power of ingredient synergy, you can construct the ultimate body recomposition strategy.

Adipose Annihilation stands on its own as the most comprehensive and effective fat burner available today.  Lean Body Formulations guarantees the first-class quality of each and every ingredient in its proprietary blend…

Garcinia Cambogia 50% HCA (Hydroxycitric Acid) is a potent plant derivative with clinically proven lipid metabolism/oxidation potential [3].  Via inhibition of Malonyl Coenzyme A, the so called “building blocks” of fat, it blocks adipose production for upwards of twelve hours after a meal [4, 5].  As HCA stops creation of new fat cells, it simultaneously prompts adipose and liver tissue to oxidize bodily fat stores.  By slowing gastric emptying, HCA lowers post-prandial glucose response [6].  Clinical supplementation with Garcinia Cambogia led to, “significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group,” and, moreover, no visceral fat regain after cessation of use [7]. Beyond this, in a hypocaloric environment – created when one begins to diet – HCA will also help limit muscular catabolism and breakdown [4].

Propionyl-L-Carnitine (PLCAR) assumes an essential duty in the DESTRUCTION COMPLEX, activating and transporting fat cells for beta oxidation [8].  Its ability to support bodily energy metabolism creates innumerable benefits in trained individuals.  One clinical study found that, “oral treatment with propionyl-l-carnitine improves maximum exercise duration and maximum oxygen consumption over placebo” [9].  Similarly, PLCAR reduces accumulation of lactic acid and amplifies peak power during exercise [10].  From a general health standpoint, PLCAR offers benefits like enhanced blood flow and cardiac function [11, 12].

Choline Bitratrate is a B Vitamin that prevents fat deposition in the liver, encourages liver fatty acid metabolism and increases subsequent oxidation [13, 14].  When paired with carnitine in medical trials, the two supplements fashioned synergistic improvements in fat mobilization.  Fat is literally flushed out of the body, in the form of urinary acylcarnitines [15].

Fucoxanthin can restrict differentiation of preadipocytes to adipocytes by means of PPARγ down-regulation.  Thus, this algae extract limits the opportunity that adipose cells have to form and accumulate in the body [16].  A cutting-edge supplement in the dieter’s arsenal, Fucoxanthin is rapidly garnering popularity as an uncoupler.  Recent Hokkaido University trials found that Fucoxanthin augmented expression of mitochondrial uncoupling protein 1 (UCP1).  In turn, UCP1 expression shrank abdominal white adipose tissue cells; resultant net body composition changes in Fucoxanthin-fed subjects were undeniably positive [17].

Octopamine HCL acts within the SHRED COMPLEX as a verified noradrenergic and dopaminergic antagonist [18].  More specifically, Octopamine’s activation of β3 receptors burn fat through two avenues: adipose tissue lipolysis and skeletal muscle thermogenesis [19, 20].  Hyperplasia of brown adipose tissue is solely attributed to the effects of β3 agonists in medical studies [21].  β3 agonists improve nutrient partitioning through the mechanisms of uptake and shuttling.  Perhaps best of all, the naturally high resistance of β3 receptors to downregulation allow Octopamine to maintain effectiveness.  Unlike other popular agonists (ECA stack, amphetamines, etc.) that quickly diminish in efficacy, Octopamine continues to produce results over a long period of time.

Rauwolfia Serpentina (Alpha Yohimbine) is a forceful α2 adrenergic antagonist; compared to standard Yohimbine, Alpha Yohimbine’s impact on α2B and α2C adrenoreceptors is three and four times more potent, respectively [22, 24].  As such, it capably enhances vasodilation/blood flow in adipose cells [23].  Because Alpha Yohimbine modulates α2C prevalent in the brain, epinephrine – along with concurrent nutrient utilization, thermogenesis, and energy metabolism – is maximally activated, whilst breakdown of serotonin, noradrenaline, and dopamine are controlled [24].

Capsaicinoids (40% Capsicium Annum Extract) increases energy expenditure and metabolic rate through multiple pathways [23, 24].  Studies claim, “capsaicin also inhibited the expression of PPARγ, C/EBPα, and leptin, but induced up-regulation of adiponectin at the protein level. These results demonstrate that capsaicin efficiently induces apoptosis and inhibits adipogenesis in 3T3-L1 preadipocytes and adipocytes” [25].  PPARγ modulation causes the bulk of adipose loss to be exhibited on ugly abdominal fat stores [26].  Capsaicinoid dosage in the SHRED COMPLEX far exceeds the potency required to experience these beneficial effects, which are a result of increased post-ingestion glycerol and blood FFA levels [27].

References:

[1] Pedersen, S. B., Kristensen, K., Hermann, P. A., Katzenellenbogen, J. A., Richelsen, B. (2004). Estrogen Controls Lipolysis by Up-Regulating {alpha}2A-Adrenergic Receptors Directly in Human Adipose Tissue through the Estrogen Receptor {alpha}. Implications for the Female Fat Distribution. J. Clin. Endocrinol. Metab. 89: 1869-1878

[2] Lee, Y. (2006). Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States Diabetes, 55 (8), 2256-2264

[3] Shara M, Ohia SE, Yasmin T, et al. (2003). "Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days". Mol. Cell. Biochem. 254 (1-2): 339–46.

[4] Sherwin RS et al.; Journal of Clinical Invest.;1975 55:1382-1390

[5] Triscari J, Sullivan AC. Comparative effects of (-)-hydroxycitrate and (+)-allo-hydroxycitrate on acetyl CoA carboxylase and fatty acid and cholesterol synthesis in vivo. Lipids 1977;12:357–63.

[6] Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1144-9.

[7] Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial.; Kohsuke Hayamizu MS et al.; Current Therapeutic Research.; Volume 64, Issue 8, September-October 2003, Pages 551-567

[8] Flanagan et al., Role of carnitine in disease Nutrition & Metabolism 2010, 7:30

[9] Ferrari, et al.(2004) Therapeutic Effects of l-Carnitine and Propionyl-l-carnitine of Cardiovascular Diseases: A Review. Annals New York Academy of Sciences. 1033:70-91.

[10] Jacobs PL, Goldstein ER, Blackburn W, Orem I, Hughes JJ. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr. 6(9): Epub Apr 2, 2009.

[11] Cittanti C. Colamussi P, Giganti M, Orlandi C, Uccelli L, Manfrini S, et al. Technetium-99m sestamibi leg scintigraphy for non-invasive assessment of propionyl L-carnitine induced changes in skeletal muscle metabolism. Eur J Nucl Med 1997; 24: 762-766.

[12] Schonekess BO, Allard MF, Lopaschuk GD. Propionyl L-carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation. Circ Res. 1995;77:726-734.

[13] Best, C. H., and M. E. Huntsman 1934 The effect of choline on the liver fat of rats in various states of nutrition. J. Physiol., 83: 255.

[14] Artom, C. (1953) Role of choline in the oxidation of fatty acids by the liver. J. Biol. Chem. 205: 101-111.

[15] Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr. 2003; 133(1):84-9.

[16] Maeda H, Hosokawa M, Sashima T, et al. (2006) Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int J Mol Med 18, 147–152.

[17] Maeda H, Hosokawa M, Sashima T, Funayama K, Miya. Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.

[18] Jagiełło-Wójtowicz E (1979). "Mechanism of central action of octopamine". Pol J Pharmacol Pharm 31 (5): 509–16.

[19] Ferrer-Lorente R, Cabot C, Fernández-López JA, Alemany M (September 2005). "Combined effects of oleoyl-estrone and a β3-adrenergic agonist (CL316,243) on lipid stores of diet-induced overweight male Wistar rats". Life Sciences 77 (16): 2051–8.

[20] Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4.  Page 163

[21] Tsukazaki, K., H. Nikami, Y. Shimizu, T. Kawada, T. Yoshida, and M. Saito. Chronic administration of 3-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. J. Biochem. 117: 96-100, 1995

[22] Timmermans PB, Qian JQ, Ruffolo RR, Jr, van Zwieten PA. A study of the selectivity and potency of rauwolscine, RX 781094 and RS 21361 as antagonists of alpha-1 and alpha-2 adrenoceptors. J Pharmacol Exp Ther. 1984 Mar;228(3):739–748.

[23] Galitzky J, Lafontan M, Nordenstrom J, Arner P. Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue. J Clin Invest 1993; 91:1997-2003.

[24] Convents A, Convents D, De Backer JP, De Keyser J, Vauquelin G. High affinity binding of 3H rauwolscine and 3H RX781094 to alpha 2 adrenergic receptors and non-stereoselective sites in human and rabbit brain cortex membranes. Biochem Pharmacol. 1989 Feb 1;38(3):455–463.

[23] Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice. Kawabata F, Inoue N, Masamoto Y, Matsumura S, Kimura W, Kadowaki M, Higashi T, Tominaga M, Inoue K, Fushiki T. Biosci Biotechnol Biochem. 2009 Dec;73(12):2690-7. Epub 2009 Dec 7.

[24] Han J. et al., Capsaicin induced the upregulation of transcriptional and translational expression of glycolytic enzymes related to energy metabolism in human intestinal epithelial cells. J. Agric. Food Chem. 2009 Dec 9, 57(23). 11148-53.

[25] Journal of Agricultural and Food Chemistry: Volume 55, Pages 1730-1736: "Effects of Capsaicin on Induction of Apoptosis and Inhibition of Adipogenesis in 3T3-L1 Cells"  Authors: C.-L. Hsu and G.-C. Yen

[26] Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.Am J Clin Nutr. 2009 Jan;89(1):45-50. Epub 2008 Dec 3.

[27] Bloomer, Richard, Robert Canale, Sid Shastri, and Sujata Suvarnapathki. "Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study." Lipids in Health and Disease 9 (July 2010): 72+.

Adipose Annihilation not only supports fantastic body recomposition, but also supplements general health through a variety of mechanisms.  Ingredients in Adipose Annihilation offer the following benefits:

v     HCA – a compound that inhibits ATP citrate lyase – may be capable of tumor growth prevention.  It is one of few organic compounds capable of chelation and elimination of toxic metals (to which citizens of industrialized countries are often exposed) from the bloodstream.  Increased calcium metabolism is another effect of HCA supplementation, helping to sustain strong bone structure [28, 29, 30].

v     Frequently described as a, “‘conditionally essential’ nutrient for humans,” Carnitine plays a vital role in cardiac metabolism and defends against ischemic heart disease – the most common cause of death in Western countries [31, 32].

v     Choline supplementation supports acetylcholine and phosphatidylcholine synthesis in the brain, leading to enhanced brain development and function [33, 34].

v     Recent medical discovery of Fucoxanthin’s ability to induce apoptosis indicates that it could serve as a chemopreventative/chemotherapeutic cartenoid to prevent and/or treat colon cancer [35].

v     Adrenergic properties of Octopamine create advantages such as improved glucose transport and lipolysis in adipose cells [36].

v     Alpha Yohimbine has been successfully utilized in multiple medical trials to treat hypertension [37, 38].

v     Reduction of low-density lipoprotein (LDL) oxidation is an effect of Capsaicinoid consumption; this effect reduces the likelihood of harmful atherosclerotic development [39].

[28] Hatzivassiliou G, Zhao F, Bauer DE, et al. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 2005; 8: 311–21.

[29] Sinicropi MS, Amantea D, Caruso A, Saturnino C. Chemical and biological properties of toxic metals and use of chelating agents for the pharmacological treatment of metal poisoning. Arch Toxicol. 2010 Jul;84(7):501-20. Epub 2010 Apr 13.

[30] Glusker, J. P. 1980. Citrate conformation and chelation: enzymic implications. Acc. Chem. Res. 13:345-352.

[31] CJ Rebouche. Carnitine function and requirements during the life cycle. FASEB J. 6: 3379-3386.

[32] Siliprandi, N., Di Lisa, F. and Menabò, R.: Propionyl-L-carnitine: Biochemical significance and possible role in cardiac metabolism. Cardiovasc. Drugs Ther. 5: suppl. 1, 11–15, 1991.

[33] Choline and Human Nutrition. S H Zeisel, J K Blusztajn. Annual Review of Nutrition 1994 14, 269-.  296.

[34] Babb SM, Ke Y, Lange N, Kaufman MJ, Renshaw PF, Cohen BM (2004) Oral choline increases choline metabolites in human brain. Psychiatry Res 130:1–9.

[35] Hosokawa M, Kudo M, Maeda H, Kohno H, Tanaka T and Miyashita K: Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. Biochim Biophys Acta 1675: 113-119, 2004.

[36] Fontana E., Morin N., Prevot D., Carpene C. Effects of octopamine on lipolysis, glucose transport and amine oxidation in mammalian fat cells (2000) Comparative Biochemistry and Physiology – C Pharmacology Toxicology and Endocrinology, 125 (1), pp. 33-44.

[37] R. W. P. Achor, N. O. Hanson, and R. W. Gifford Jr. Hypertension treated with Rauwolfia Serpentina (whole root) and with reserpine: controlled study disclosing occasional severe depression JAMA, October 29, 1955; 159(9): 841 – 845.

[38] WILKINS RW, JUDSON WE. The use of Rauwolfia serpentina in hypertensive patients. N Engl J Med. 1953 Jan 8;248(2):48-53.

[39] Effects of Capsaicin, Dihydrocapsaicin, and Curcumin on Copper-Induced Oxidation of Human Serum Lipids. Kiran D. K. Ahuja,, Dale A. Kunde,, Madeleine J. Ball, and, Dominic P. Geraghty Journal of Agricultural and Food Chemistry 2006 54 (17), 6436-6439.