Slin-Sane & Protocol Stack (1 + 1 Units)

Slin-Sane & Protocol Stack: Extreme Pump, Endurance, Recovery...REAL RESULTS!

LIMITED TIME ONLY: Buy These Two Synergestic Products Together & SAVE BIG BUCKS!

Each Stack Includes the Following:

1X NEW Slin-Sane (60 caps)

1X NEW Protocol (495 grams) (IMPROVED FORMULA & TASTE!)

Genomyx' Slin-Sane: Skin Bursting Pumps!

Physique athletes have long since realized the profound benefits of the myotropic hormone insulin, whether it be through maximizing endogenous timing and release or simply by injecting the exogenous compound. Insulin release is stimulated in the body simply by the ingestion of carbohydrates, certain amino acids, or the combination of both. However, many people have inherent dysfunction in the complex insulin signaling cascade, which can result in limited nutrient uptake by the muscle cells, excessive uptake by the fat cells, too much insulin released, or too little insulin released. Even those with proper nutrient signaling can still greatly benefit their quest for increased muscle gain and accelerated fat loss by optimizing the body’s nutrient storage capabilities.

Slin-Sane was designed to be just that nutrient storage optimization tool, by working to maximize uptake of glucose and amino acids at the muscle cell through multiple angles similar to and in conjunction with insulin, while delivering increased vascularity and muscle fullness.

Overview of ingredients and function for Slin-Sane:

Lagerstroemia Speciosa

A small to medium sized tree grown throughout parts of southern Asia, the leaves of Lagerstroemia Speciosa (LS) yield a novel compound called Banaba. Commonly used in Phillipine folk medicine to treat symptoms of diabetes, this compound shows great promise for its multi-faceted beneficial interaction with glucose and insulin.

Initially, researchers thought banaba’s positive effects to be solely related to its content of corosolic acid, but studies have since shown there may be multiple other compounds in the leaf that contribute to its numerous benefits.

Multiple studies have shown LS to have the ability to increase translocation of the GLUT4 receptor at the muscle cell, therefore allowing increased nutrient uptake (1,9). This cellular receptor is the main gatekeeper for nutrient influx, and optimal expression can greatly enhance cellular storage capabilities, increasing muscle fullness.

A recent study out of Japan found a significant reduction in blood glucose response after feeding sugar to subjects pretreated with LS versus subjects who didn’t take the supplement (2). A similar study published in Diabetes Research and Clinical Practice also showed a potent glucose lowering effect over control from ingestion of 75g of glucose after administration of LS (6). In addition to reduction in glucose response to food intake, LS has been shown in multiple studies to lower fasting glucose and insulin levels, a key marker in overall health and cell responsiveness to nutrient sensing (3,8,10,13).

Aside from Lagerstroemia’s basic glucose stabilizing effects, it touts numerous other capabilities related to health and longevity including elevating insulin sensitivity (8), lowering free fatty acids, blood pressure, CRP, and oxidative stress (7), suppression of adipocyte differentiation similar to AICAR (5), reducing triglycerides and A1C levels (8), and significantly lowering hepatic lipid content (11).

Looking at things purely from a body composition angle, LS can help promote the muscle building effects of insulin by mimicking the hormone and working through an independent mechanism of insulin itself (12), act anti-catabolically to prevent muscle breakdown (4), lower fasting glucose/insulin levels, and increase insulin sensitivity to aid in fat loss and muscle gain.

Lagerstroemia Review

• Enhances glucose uptake at muscle cell
• Reduces fat gain from a high fat diet
• Lowers blood glucose response to feeding
• Reduces fasting glucose, insulin, triglycerides, FFA’s, CRP and A1C
• Increases insulin sensitivity and GLUT4 translocation
• Increases adiponectinGymnema Sylvestre

Gymnema Sylvestre

Used as a natural treatment for diabetic symptoms in parts of India for thousands of years, this tropical herb has many promising attributes for the modern day physique enthusiast. Much of the research on this compound has focused on diabetic conditions, with some pretty incredible results.

Studies have shown Gymnema to reverse elevated cholesterol and triglycerides (15,17,26), decrease serum blood glucose in a fasted and fed state (16,20,22,24,26), and improve the time it takes to clear glucose from the bloodstream post-prandially (24). A long term study out of India looked at diabetics who had been given Gymnema daily for up to a year, and found that fasting glucose levels had dropped from an average of 232 mg/dL to a remarkable 152 mg/dL, with no change in the control group. The Gymnema group was able to halve their required insulin dosages over the course of the study, and they also showed a significant drop in A1C levels (22), which was later confirmed by a 2009 study in the journal Phytomedicine (26).

Gymnema has a profound effect on the insulin secreting cells of the pancreas, known as the beta cells located inside the islets of Langerhans. The herb has the unique ability to stimulate insulin release, even without the presence of carbs (18), and can actually regenerate the beta cells that often become damaged and dysfunctioning over time (22). One study published in the Journal of Ethnopharmacology even found Gymnema to double the number of beta and islet cells in diabetic rats (23).

Aside from the profound effects on pancreatic function, Gymnema also acts at nutrient destination cells by increasing permeability of cell walls, which assists in the process of nutrient uptake (18). Damaged cell walls become less permeable over time, due to excess insulin in the bloodstream and dietary deficiencies, among other things. Gymnema acts as sort of a cellular repair kit, restoring optimal function.

The addition of Gymnema alongside Lagerstroemia to Slin-Sane allows for a two-pronged attack for optimization of glucose and insulin. By increasing the enzymes responsible for glucose utilization (25), enhancing the action of endogenous insulin (22), stimulating insulin release and repairing beta cells, increasing cell permeability and repairing insulin induced damage to the liver, kidney and muscle cells (25), Gymnema will aid in driving nutrients into the muscles for a full, pumped feeling and increased performance.

Gymnema Review:

• Stimulates insulin release and mimicks insulin
• Increases nutrient uptake
• Increases cell permeability
• Reduces serum glucose, cholesterol, triglycerides, and A1C
• Elevates HDL levels
• Regenerates pancreatic cells

L-Norvaline

An analogue of the branched chain amino acid L-Valine, this compound was chosen due to its vasodilating properties for an increase vascularity, muscle pump, and nutrient delivery.

L-Norvaline works by inhibiting the arginase enzyme, which is responsible for the breakdown of L-Arginine into L-Ornithine and urea (28-30). An animal study published in the American Journal of Heart and Circulatory Physiology found that L-Norvaline increased Nitric Oxide production by 55% (28).

L-Norvaline Review:

• Increases Nitric Oxide production
• Causes vasodilation and muscle pump

Slin-Sane Overview:

• Enhances vasodilation and muscle pumps
• Elevates nitric oxide
• Drives nutrients into cells
• Stimulates insulin release, mimicks insulin and enhances insulin’s endogenous effect
• Reduces fasting glucose and insulin
• Reduces glucose response to meals
• Reduces fat gain and speeds up fat loss
• Regenerates pancreatic beta cells
• Supports healthy blood lipids
• Lowers liver lipid content (major factor in cardiovascular disease)
• Increases plasma adiponectin

1. When should I take Slin-Sane, and do I need to cycle it?

Slin-Sane should be taken before carbohydrate heavy meals (30g or more). Take 1 capsule about 15 minutes before you start eating. If you’re using it every day, you may want to take a couple of weeks off after a month of use as its generally a good idea to cycle any supplement, although studies have used the ingredients for long durations with no ill effects.

2. How do I use Slin-Sane for a muscle building phase?

You should be able to increase your carbohydrate intake higher than a normal “bulking” phase with the use of Slin-Sane, due to its favorable nutrient partitioning effects you won’t have to worry about excess fat gain. Take 1 capsule before 3 carbohydrate heavy meals and up your carbs by about 20-30% above intake for normal muscle building phases. Be sure to take a serving before your workouts, and sip on a fast absorbing carb+protein shake while training. You should notice a significant increase in pump and vascularity during the workout, and noticeably faster muscle gain over the course of usage.

3. How do I use Slin-Sane for a fat loss phase?

Again you should be able to lose fat on a slightly higher carb intake than normal, but you’ll want to cut your carb intake down significantly from a muscle building phase. You can try timing most of your daily carbs around weight training (a shake during the workout and one carb heavy meal after), and take a serving of Slin-Sane before each. You can also spread your carbs out into three meals throughout the day with a serving of Slin-Sane before each. You should notice accelerated fat loss over the course of usage.

4. Can I take Slin-Sane without carbs?

This is not recommended due to its hypoglycemic effects; however certain advanced users may want to experiment with Slin-Sane before meals on a very low carbohydrate or ketogenic diet. Just be sure to have some carbs around in case hypoglycemia starts to sneak up on you, as it can be fairly uncomfortable.

5. Can females use Slin-Sane?

Absolutely. Slin-Sane works the same way in women as it does in men, and none of the ingredients exhibit any sort of gender specific effect.

6. Slin-Sane safe to stack with other supplements?

Definitely. Slin-Sane is safe with most other supplements, just watch out for anything that is known to lower blood glucose or increase insulin sensitivity. You should avoid any of the various forms of Alpha Lipoic Acid at the same meal as Slin-Sane, and you may want to time fish oil with meals away from the Slin-Sane, or use a lower dose than normal at the same meal.

Protocol: Advanced Recovery, Endurance, & Performance!

**New Delicious Cherry Flavor!

Research and empirical evidence have shown time and time again that immediately after weight training, taking advantage of specific physiological changes can exponentially accelerate changes in body composition and performance. With Protocol, not only will you allow your body to maximize the endogenous changes already caused by training, but you can actually create a perfect muscle building environment by driving your body’s nutrient storage and muscle protein synthesis capabilities to a new level.

Protocol was designed to be taken immediately after weight training to kick start protein synthesis and perfectly harmonize your body’s hormonal cascade priming it for a post workout meal or shake. Take a serving of Protocol right after training, wait 15 minutes and have a high carbohydrate, high protein shake or meal. For fat loss programs, take a serving of Protocol, wait 15 minutes and have an isocaloric (equal parts carb, protein and fat) mixed meal. The end result will be faster muscle gain and accelerated recovery, fully preparing your body for the next training session. On non-training days, take a serving 15 minutes before your first meal. See FAQ for multiple serving recommendations.

Overview of ingredients and function for Protocol:

L-Leucine:

Leucine is a Branched Chain Amino Acid (BCAA’s) concentrated highly in eggs, milk, beef, chicken and fish. Since Leucine is one of the few amino acids not metabolized by the liver, intake directly affects cellular concentrations (1). Numerous studies have looked at the ability of Leucine to prevent muscle protein breakdown and increase muscle protein synthesis (MPS) rates with promising results (1-13). It seems that Leucine acts as a primary signal alerting the body of amino acid availability for protein synthesis. This signaling causes an up-regulation of relevant myotropic machinery, especially in conjunction with insulin (2).

While insulin seems to enhance the effect of Leucine, multiple studies have proposed an additional non-insulin dependent effect of Leucine on MPS, which most discussions on the topic have overlooked (2,3,11). The relevant message is that Leucine will cause an anti-catabolic and/or myotropic effect on its own through non insulin-dependent mechanisms, and will also have an additional effect when coupled with insulin from concurrent carbohydrate ingestion.

While all of the mechanisms Leucine uses to deliver its effects on muscle tissue have yet to be elucidated, we know that it has a profound effect on mTOR activation, a key regulator of MPS (1,7,9). Aside from the well documented mTOR effect, Leucine may also have muscle building effects unrelated to this pathway, as noted by Kimball and Jefferson in a 2001 study which found elevated muscle protein synthesis with no significant increase in mTOR signaling proteins (4).

Another way Leucine exhibits its beneficial effect on body composition is through its lesser known ability to increase muscle cell insulin sensitivity (2). It seems that available Leucine directly translates to increased uptake of all nutrients at the muscle cell, therefore creating an immediate increase in muscle growth. Resistance training alone has been shown to upregulate MPS when adequate calories are supplied, yet the addition of Essential Amino Acids (EAA’s, which include Leucine) causes a much greater elevation (8).  While initial studies on post workout MPS focused on BCAA’s and EAA’s, later studies have shown that Leucine is the primary contributor to accelerated muscle tissue accretion, having the same or greater effect when taken alone vs. conjunction with the other BCAA’s/EAA’s (2,8,10).

Garlick PJ, Grant I. 1988. Amino Acid infusion increases the sensitivity of muscle protein synthesis invivo to insulin. Biochem J. 254:579-584.

Leucine is truly a wonder supplement when trying to retain lean body mass on a calorie restricted diet. Studies have shown supplemental Leucine to retain LBM in a hypocaloric state and even suppress protein breakdown after 18 hours of starvation (1,5,6). While most weight training aficionados have known for some time that the RDA for protein is far from optimal when trying to change body composition, new research has confirmed that during caloric restriction, daily requirements of certain amino acids, particularly Leucine, are drastically understated. In a 2008 review titled “Leucine for retention of lean mass on a hypocaloric diet”, researchers looked at a study that put various subjects on a 500 calorie/day deficit with various macronutrient intakes. The group on a high protein/high Leucine diet lost more weight, more fat, and showed greater LBM retention. Leucine supplemented groups have also shown more visceral fat loss than controls, which aside from being unsightly, is the deep abdominal fat known for wreaking havoc on the entire body. This review also covered Leucine’s ability to control appetite through hypothalamic regulation, truly pointing to leucine as a dieter’s best friend (1).

Whether using leucine to accelerate protein synthesis during a muscle gaining phase or minimize muscle loss and accelerate fat loss while dieting, it should certainly hold a place in any physique enthusiast’s repertoire and represents a crucial component in the Protocol formula.

Leucine Review:

• Activates mTOR
• Significantly elevates muscle protein synthesis
• Reduces muscle protein breakdown
• Reduces muscle loss on hypocaloric diet
• Increases muscle cell insulin sensitivity
• Provides a muscle building effect in conjunction with insulin
• Increases muscle growth through insulin-independent mechanisms
• The only amino acid to independently switch on muscle building cascade

L-carnatine L-Tartrate:

L-Carnitine L-Tartrate (LCLT) is a combination of the amino acid L-Carnitine and the salt of tartaric acid, with numerous potential benefits for those looking to improve body composition, performance and overall health.

One of LCLT’s major benefits stems from its ability to directly enhance recovery from exercise, allowing for faster muscle building and fat loss. Studies have shown supplementation with LCLT can reduce the metabolic stress of exercise, enhance ammonia clearance at the muscle causing a favorable shift in pH, speed recovery, and even reduce muscle soreness (15,17,19,21). Reduced soreness may not be a big seller for some people that don’t mind a little post training pain, but looking at it in big picture terms, this may allow you to train again sooner and get more effective and frequent training sessions in throughout the week, month, or year leading to accelerated progress.

In a placebo controlled study published in 2008 by the big dogs William Kraemer and Jeff Volek (among others), the researchers found that ingestion of 2g/day of LCLT favorably shifted muscle cell oxygenation, (the balance between oxygen delivery and oxygen consumption) by enhancing oxygen consumption at the muscle cell (16).  This can have favorable effects in anaerobic as well as aerobic training.

LCLT has also gained recent attention due to its ability to favorably affect myotropic hormone signaling through multiple mechanisms. In a groundbreaking study published in Med Sci Sports Exerc., researchers found LCLT was able to increase muscle cell androgen receptor density which gives testosterone more sites to “dock”, and therefore could potentially kick start a large muscle building cascade (18). This is extremely beneficial for athletes choosing to use exogenous sources of testosterone as well as natural trainees. Aside from optimizing endogenous and exogenous testosterone binding ability, ingestion of 2g/day of LCLT for 3 weeks also significantly elevated IGF-1 levels in study subjects, another key myotropic hormone which aids in muscle gain (19).

Aside from the numerous exciting benefits, LCLT has also been deemed to be safe, researchers finding no adverse effects from daily supplementation (20).

L-Carnitine L-Tartrate Review:

• Increases androgen receptor density
• Elevates IGF-1 levels
• Reduces markers of metabolic stress to exercise
• Decreases post workout soreness
• Speeds recovery from training
• Enhances muscle cell oxygen consumption

Agamtine Sulfate:

Arginine is an amino acid that has made its way into countless bodybuilding supplements in the past few years, surrounded by endless promises about enhanced muscle pumps and heightened nutrient delivery. Most people have realized the incredulous amount of hyperbole involved in these claims and have begun to accept its muscle building potential to be far less than originally theorized. What does arginine have to do with agmatine? Once arginine is decarboxylated, it becomes agmatine. This decarboxylation entirely changes the nature of the compound in the body, so much so that agmatine is involved with even more metabolic processes than arginine itself.

Agmatine takes a two pronged attack at nitric oxide elevation, by increasing NO synthesis as well as being an irreversible inhibitor of Nitric Oxide Synthase, which is the enzyme responsible for degradation of NO (24,27,28). By effectively elevating NO and decreasing its breakdown, the much sought after effects of increased vasodilatation and nutrient delivery to the muscle cells can be maximized. While it is debatable whether an increase in NO pre-workout is beneficial, most experts agree that a post workout elevation of NO can be highly useful for muscle recovery and enhancing the muscle building signal cascade.

Agmatine is normally released endogenously in response to stress and inflammation, by supplementing with an exogenous source one can maximize its effect on recovery (27). When using agmatine immediately after workouts, the nutrients digested in a post workout meal or shake can be more effectively delivered to the muscle cells for enhanced recovery and muscle growth.

In addition to increased nutrient delivery to muscle cells, agmatine also acts to aid nutrient uptake by increasing muscle cell insulin sensitivity through activation of I(2)-imidazoline receptors (25). So agmatine not only helps you get the glucose and amino acids to the right place, it also opens the door and drives them right inside the muscle cell to enhance protein synthesis.

Aside from the potent effects at the muscle cell, agmatine also possesses some interesting psychological effects. Studies have shown it to be neuroprotective by blocking the damaging effects of excessive glutamate, act as an anti-depressant and MAOb inhibitor, and even modulate and reverse opiate tolerance (22,26,27,28). Agmatine also has a beneficial effect on calcium homeostasis by reducing cellular calcium overload, lowers blood pressure, and has various beneficial effects on the heart (23,24).

Agmatine Sulfate Review:

• Increases Nitric Oxide synthesis
• Inhibits Nitric Oxide breakdown
• Enhances nutrient delivery to muscle cells
• Raises muscle cell insulin sensitivity
• Neuro-protective
• Mood elevating

Beta Alanine:

For many years now research has continued to support the usage of this amino acid derivative for performance enhancement. Working in a similar, yet more efficient fashion as Citrulline Malate, Beta Alanine increases muscle carnosine levels allowing for improvement in multiple areas of physical performance (29,33,36). 

By buffering hydrogen (H+) ions, it allows for an increase in aerobic and anaerobic performance especially muscular endurance in weight training and short and long duration sprinting (29,31,33,36). A 2009 study showed even an increase in peak sprint power output by over 11% (29). Another recent study published in the peer reviewed journal Amino Acids showed that supplementing with Beta Alanine was able to increase muscle carnosine levels by as much as 64%, and low doses still caused an elevation over 40% (36). Beta alanine has also been shown to prevent the drop in blood pH seen in high intensity exercise, which may be a significant contributor to its ability to improve exercise performance (37).

Aside from improving muscular endurance, strength athletes that train in low rep ranges can also benefit from Beta Alanine supplementation to decrease fatigue and increase total training volume (30). When training primarily with low reps, users will see the most benefit later in the workouts, by being able to add sets and experience less drop off due to fatigue accumulation.

Beta Alanine Review:

• Increases muscle carnosine levels
• Buffers hydrogen ions
• Increases muscular endurance
• Delays onset of muscular fatigue
• Allows for increased training volume
• Increases peak sprint power output

Protocol Overview:

• Activates mTOR
• Elevates muscle protein synthesis
• Reduces muscle protein breakdown
• Reduces muscle loss on hypocaloric diet
• Increases muscle cell insulin sensitivity through multiple angles
• Provides a muscle building effect with our without insulin
• Reduces markers of metabolic stress to exercise and speeds recovery from training
• Decreases post workout soreness
• Increases androgen receptor density
• Elevates IGF-1 levels
• Increases Nitric Oxide synthesis
• Inhibits Nitric Oxide breakdown
• Enhances nutrient delivery to muscle cells
• Increases muscle carnosine levels
• Buffers hydrogen ions
• Increases muscular endurance
• Allows for increased training volume
• Neuro-protective
• Mood elevating