Applied Nutriceuticals Research has recently developed one of the strongest non-steroidal products on the market, by applying the principles of Ayurvedic medicine and modern-day chemistry. Creatine Ethyl Ester (creatine monohydrate with an Ethyl Ester attached to maximize bio-availability) has been used for several years by athletes to increase size and strength (2). The compound plays a vital role in cellular energy production, by regenerating ATP in skeletal muscle. This is very important, because without ATP, muscle contraction is not possible (2). Another important component of NeoVar, Banaba, is a medicinal herb that grows in India, Southeast Asia, and the Philippines. It has been used for centuries as a treatment for hyperglycemia and diabetes, and the hypoglycemic effect of banaba is very similar to that of the hormone insulin (8,9,10). Insulin is a crucial hormone in creatine transport, as it is necessary for the deposition of creatine phosphate in skeletal muscle. The third component of NeoVar, Rhodiola Rosea, has been shown to increase ATP and creatine phosphate, while enhancing energy metabolism in skeletal muscle and increasing protein synthesis (15). With NeoVar, The Applied Nutriceuticals Research Team has discovered a specific product formulation and spent countless hours testing it on athletes- and we pass this research-based knowledge on to you through our products!!
The ATP-PCr System, Maximizing CP Stores, and Glucose Metabolism
ATP stands for adenosine triphosphate, which is an energy molecule produced in the mitochondria of the cell. As a muscle contracts, ATP provides the energy necessary for cross-bridge cycling which enables forceful muscle contraction. Unfortunately, skeletal muscle has very limited reserves of ATP- only around 4 to 6 seconds, just enough to get an athlete moving (2). ATP is the only energy source used directly for muscle contraction, and it must be renewed as fast as it is broken down for contraction to continue. During intense exercise, like sprinting or weight training, ATP is hydrolyzed to ADP (adenosine diphosphate) and inorganic phosphate. Fortunately, ATP can be regenerated in a fraction of a second by the interaction of ADP and creatine phosphate (CP) (2). CP is a potent molecule stored in the muscles, and is mobilized to regenerate ATP when a higher demand occurs (like during strenuous exercise). Muscle cells store a great deal more CP than they do ATP, and CP will readily donate its phosphate to ADP to produce ATP. Therefore, the more CP that is available within the cell, the more ATP will be produced which results in more energy, and stronger muscle contractions.
Creatine supplementation has been shown to increase intramuscular creatine stores to varying extents (5). Most research states that the more creatine skeletal muscle can hold, the greater the benefits provided from the compound. Creatine provides a variety of anabolic effects on skeletal muscle, in addition to being a source of ATP. Studies have shown that creatine increases both total and fat-free body mass (1,5). Increased CP inside the muscle cell is a powerful anabolic stimulus for muscle hypertrophy. Greater CP stores within skeletal muscle result in an increase in intracellular water, which raises osmotic pressure within the cell. High intracellular osmotic pressure triggers heightened protein synthesis and nitrogen retention (3). This is important, because both of these factors are responsible for lean body mass gains. Most simply put, the more creatine you can hold in your muscles, the more your muscles will recover and grow.
There are many other potential benefits to creatine supplementation. Creatine has been shown to boost the activity of myogenic cells, which are satellite stem cells that have the ability to turn themselves into new muscle cells if instructed to do so by the genetic code of the body. These satellite cells fuse with an adjacent damaged muscle fiber, thereby increasing myonucleii numbers necessary for growth and repair (4). This process of myogenic maturation is called hyperplasia, and the subsequent new muscle cells formed by hyperplasia also have the ability to enable muscle hypertrophy if combined with weight training.
As we know, creatine supplementation has been shown to increase intramuscular creatine stores, but to greatly varying extents (6). Most manufacturers suggest loading, but various strategies have been used in attempts to increase total creatine concentration within skeletal muscle (1,2,3,4,5,6). In the early 90's researchers discovered that ingesting creatine w/ high glycemic carbohydrates such as dextrose dramatically raised skeletal muscle concentrations of creatine beyond regular oral supplementation alone. Up to 60% increases were noted in some subjects (a 20% raise is considered normal in most studies) using these methods (6), but the results varied greatly. While moderately effective, these techniques fall short because most ingested creatine is still not absorbed. The unabsorbed creatine accumulates outside of the targeted cells, causing a multitude of negative side effects including bloating, cramping and dehydration. The Applied Nutriceuticals researchers have taken notice of these findings, and have further researched compounds that can further aid in greater uptake of intramuscular creatine.
Creatine Monohydrate vs. Creatine Ethyl-Ester
Creatine ethyl-ester contains a lipid soluble component (the actual ethyl ester), which allows it to absorb into skeletal muscle cells more readily. This allows the user to be able take less creatine, with greater benefits.
The ingestion of high glycemic carbohydrates (such as dextrose, fructose, and sucrose) causes a large increase in blood glucose, and concurrent to this rise in blood glucose, a surge (or “spike”) of insulin (a polypeptide anabolic storage hormone) is released from the pancreas in order to control the amount of sugar in the blood (6). Insulin is particularly effective in transporting creatine and blood glucose into skeletal muscle. However, insulin can be a double-edged sword, in that while it can cause an increased deposition of glucose, protein and creatine into the muscles, it can also increase fat deposition as well.
Ideally, what was needed was a compound that directly mimics insulin and is safe for everyone to use, and would help athletes gain more muscle from the creatine they take. This is where another ingredient of NeoVar, Banaba Extract, comes in. While Banaba has been used for years in Eastern medicine to control diabetes, it is a very new compound to Western medicine. Corosolic acid (the active ingredient in Banaba) closely mimics insulin by SAFELY stimulating much greater glucose and creatine phosphate transport into cells, by translocating GLUT4 while not allowing plasma insulin levels to increase (7). In some head-to-head studies with insulin, Banaba actually performed just as well as insulin at controlling blood sugar in patients with Type II diabetes (7,8,9,10). While Banaba has a mechanism of action similar to insulin, it does have a distinct advantage over insulin, in that it is not an “equal opportunity” deposition agent, like insulin. In other words, insulin can be problematic and beneficial at the same time, in that while it can increase deposition of glucose, protein and creatine into the muscles, it can also have a negative effect by increasing body fat levels. Plus, when the body produces too much insulin over time, it begins to become insensitive to the hormone (12). Insulin insensitivity results from a down-regulation of insulin receptors on target tissue, and also a subsequent decrease in GLUT4. GLUT4 (muscle facilitative glucose isoform 4) regulates the amount of glucose allowed into skeletal muscle cells (7). Put simply, GLUT4 translocation from banaba extract helps you drive more creatine into your muscles.
Corosolic Acid (the active ingredient in Banaba Extract) has been shown to increase GLUT4 translocation in diabetic patients, allowing for greater glucose disposal in the muscle cells, while keeping plasma insulin levels the same, meaning that the intake of Banaba Extract as an insulin mimicking/glucose control agent has actually been shown to have significant nutrient repartitioning effects (7,8,9,11,12). In this case, nutrient repartitioning means that while creatine, glucose, and protein are being deposited in the muscle cells, fat is not being deposited in adipocytes (fat cells), as is the case with insulin. This is very important, because the more simple carbohydrates ingested after a workout, the more blood glucose (and creatine) there is deposited into the muscle. (7,8,9,10,11,12). This can help the athlete retain a more positive nitrogen balance, thus enhancing recovery and building muscle.
The final ingredient of NeoVar, Rhodiola Rosea, has been shown to increase ATP and creatine phosphate stores in numerous studies. At the Tomsk State University and Medical Institute in Russia, mice were given Rhodiola supplementally and made to swim to exhaustion twice a day for six days. At the end of the testing period, muscle biopsies were performed, with the Rhodiola-treated mice having 17% greater ATP levels, 45% greater creatine phosphate stores, and 53% greater muscle glycogen levels, along with lowered intramuscular concentrations of lactic acid and ammonia (13,16,17,18). It also has been shown to enhance learning, memory, and allow for greater adaptation to stress and stress hormones such as corticotropins and catecholamines (13,14,15,16,17,18). Applied Nutriceuticals Research has developed the most potent and efficient creatine available.
No other product on the market today can deliver what NeoVar does…so why waste your time and money on second-best?
1. Hultman E, Soderlund K, Timmons JA, et al. (1996) Muscle Creatine Loading in Men.
J Appl Physiol (81): 232-37.
2. Juhn MS, (2003). Popular sports supplements and ergogenic aids. Sports Med. 33 (2): 921-39. PMID 12974658.
3. Powers ME et al. (2003) Creatine Supplementation Increases Total Body Water Without Altering Fluid Distribution. Journal of Athletic Training 38 (1): 44-50 PMID 12937471.
4. Dangott B, Schultz E, Mozdziak PE. (2000). Dietary creatine monohydrate supplementation increases satellite cell mitotic activity during compensatory hypertrophy. International Journal of Sports Medicine 2000 Jan (21(1) 13-16 PMID 10683092.
5. Stout JR et al. (1997) The effects of a supplement designed to augment creatine uptake on anaerobic reserve capacity. NSCA National Conference Abstract.
6. Tarnopolsky MA, Parise G, Yardley NJ et al. (2001). Creatine-dextrose and protein-dextrose induce similar strength gains during training. Med Sci Sports Exerc. 33 (12): 2044-52 PMID11740297.
7. Department of Clinical Nutrition, Suzuka University Medical Science (2004). Corosolic Acid induces GLUT4 translocation in genetically type 2 diabetic mice. Biol Pharm Bull 2004 Jul. 27(7): 1103-5.
8. Judy WV, Hari SP, Judy JS, Naguib YM, Passwater R et al. (2003). Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependant study. J Ethnopharmacol 87(1) 115-117.
9. Miura T. et al. (2006). Antidiabetic effects of corosolic acid in KK-Ay in diabetic mice. Biol Pharm Bull 29(3): 585-587.
10. Fukushima M. et al. (2006). Effect of corosolic acid on postchallenge plasma glucose levels. Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, 1-5-4, Minatojimaminamimachi, Chuo-ku, Kobe, Japan.
11. Liu L. et al. (2001). An Extract of Lagerstroemia speciosa L. Has Insulin-Like Glucose Uptake-Stimulatory and Adipoctype Differentiation-Inhibitory Activities in 3T3-L1 Cells. J of Nutr. 131: 2242-47.
12. Hong H, Maeng W (2004). Effects of malted barley extract and banaba extract on blood glucose levels in genetically diabetic mice. J Med Food. 7(4): 487-90.
13. Saratikov AS et al. (1987). Rhodiola Rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University Press.
14. Sandberg F (1998) Herbal Remedies and Herbal Magic. Stockholm, Sweden: Det Basta; p. 223.
15. Narr H, (1993) Phytochemical and Pharmacological investigation of the adaptogens: Rhodiola crenata and Rosea {dissertation}. Munich, Germany: Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-Universtat MYchnen.
16. Salnik BU (1970) Effect of several stimulators on central nervous system energy metabolism during muscular workload {dissertation}. Tomsk, Russia: Tomsk State Medical Institute.
17. Adamchuk LB (1969) Effects of Rhodiola on the process of energetic recovery of rat under intense muscular workload {dissertation}. Tomsk, Russia: Tomsk State Medical Institute.
18. Revina TA (1969) Effect of stimulators of the central nervous system on carbohydrate and high energy phosphorylated compound metabolism in the brain during intense muscular workload {dissertation} Tomsk, Russia: Tomsk State Medical Institute.
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Directions:
Take first dose with a meal containing at least 50 grams of complex carbohydrates. On non-workout days, repeat the same pattern for the second dose. On workout days, take NeoVar immediately following workout, along with at least 50 grams of complex carbohydrates.
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DOSAGE CHART:
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Body Weight
(pounds) |
Divided Doses
(2X a Day) |
| Up to 150 |
3 Capsules |
| 250 |
4 Capsules |
| 250+ |
5 Capsules |
WARNING:
Keep out of the reach of children. Not for use by pregnant or nursing women, or persons under the age of 18. This product is intended for use by healthy individuals only. Always consult a physician before beginning this or any dietary supplement and/or training program.
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