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Rating: 3.6923/5 (13 votes cast) | View All 1 Reviews

Axon (90 Caps)

Manufactured By: Antaeus Labs

Price: $72.99$17.71

Availability: Currently Out Of Stock

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Antaeus Labs' Axon: Long-Acting Superior Stimulant!

Looking For The Newest Breakthrough In Energy Stuimulants? Then Axon is The perfect Fit For You!

  • Long-acting stimulant.
  • Potent inhibitor of norepinephrine, dopamine, and serotonin reuptake.
  • Supports mood, focus, wakefulness, and mental clarity.
  • Facilitates optimal CNS function.
  • Combined with 60mg of caffeine per capsule for quicker-onset energy.
  • Can be used to support fat-loss, or as a general work/study stimulant.
  • Unique, patent-pending active ingredient.

Antaeus Labs' AXON is based on a triterpene known as Hederagenin -- extracted from Hedera Helix. This triterpene is a triple monoamine reuptake inhibitor: A high-affinity substrate for the dopamine, 5-HT, and norepinephrine neural membrane transporters. (DAT, SERT, and NET, respectively.) Before we expound on this specific function any further, a few general words on how these monoamine neurotransmitters work...

The human brain contains billions of neurons which release neurotransmitters. They all consist of a cell body (the soma) & a long chain (the axon) which connects via branches to other neurons. Transmission via the axon is how one cell can influence others, and this is often carried out via monoamines such as DA, NE, 5HT; in response to electrical stimuli, they are released from the axon terminal into the synaptic gap, where they seek out and bind to receptors on the other side of the gap, on other neurons. This binding is not permanent: most of these monoamines are shaken-off their receptors in a matter of milliseconds, and are then 'available' once again. Their function is terminated by monoamine reuptake from the synaptic cleft back into the neuron via membrane-bound transporter proteins. (Glycoproteins, typically.) Following reuptake, most are metabolized into inert derivatives, and some are recycled and re-released.

...As you can imagine, when reuptake proteins are inhibited, monoamine breakdown comes grinding to a halt and they start accumulating outside neurons -- eventually flooding synapses & increasing transmission to supraphysiological levels. That's the whole point. Reuptake-inhibition makes for a powerful stimulant. Although Hederagenin has its mechanism of action in common with some banned chemicals, no ingredient previously released as a supplement is anything quite like it. Ephedrine, for example, is a potent NET inhibitor, but has an extremely weak effect on dopaminergic transmission and no effects at all where the serotogenic pathway is concerned.

By increasing dopaminergic, adrenergic, and serotogenic transmission, you get an increase in energy levels, heightened focus, an elevated mood, increased confidence and drive, and an revved-up metabolic rate.
And there is another interesting and potentially-useful effect: α-hederin, a hederagenin saponin present in high quantities in Hedera Helix (and therefore AXON), prevents β2-adrenoceptor internalization and desensitization. In doing so, it strongly increases the binding potential of these receptors to other ligands. It is therefore likely that AXON has a synergystic effect with compounds which target and bind to the β2-adrenoceptor.

AXON can be stacked with other non-stimulant fat burners. It is completely safe for human consumption, and has been side-effect free in all of our testers.

Use as part of a weight-loss regimen, to increase performance and endurance in the gym, or for the long-lasting energy you need to cope with a busy work or study schedule!"

Where Pharmacokinetics Are Concerned:

Hederagenin is very lipophilic & nearly-insoluble in water. It is slowly and poorly absorbed from the GI tract, but the half-life & duration of effect of the absorbed fraction is long. (6-8+hrs.) As has been conclusively shown with another triterpene, boswelic acid, absorption and bioavailability will increase tremendously when taken with food.

 

Axon Q&A: A Discussion Between NutraPlanet & Antaeus Labs:

NutraPlanet: "What's in Axon, and what does the product actually do?"

Antaeus Labs: "Axon contains 60mg caffeine and 700mg Hedera Helix extract (standardized to 20% Hederagenin) per serving."

Caffeine is perhaps the single most ‘tried and tested’ sports supplement. The ergogenic effects of caffeine are extremely well documented, and include improved concentration and alertness, a reduction in the perceived effort during endurance exercise, increased endurance performance, and endurance performance capacity.

Hederagenin is considerably less famous, but it is an extremely interesting and potentially useful compound. For starters, oral administration of the triterpene Hederagenin has been demonstrated to have significant activity in rats and mice, which are believed to be a result of increased transmission of the monoamines serotonin, norepinephrine (noradrenaline) and dopamine. Indeed, extracellular levels of all of these hormones were significantly increased in the rat frontal cortex after oral administration of hederagenin at a dosage of 50mg/kg. The peak increases in 5-HT (serotonin), NE (norepinephrine), and DA (dopamine) were over 400% of baseline.
When the reasons behind these increases were examined, it was found that hederagenin interferes with normal monoamine reuptake by binding to the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) – in fact it has a higher affinity than the reference compounds (fluoxetine and nomifensine, respectively,) for SERT and NET. 

By increasing dopaminergic, adrenergic, and serotogenic transmission, one can expect to notice an increase in energy levels, heightened focus, an elevated mood, increased confidence and drive, and a revved-up metabolic rate. That, in a nutshell, is why we released this product.

There's more: Because of the effectiveness of ivy-leaf extracts at treating coughs and catarrh, the β2 adrenergic effects of the monodesmoside α-Hederin (a water-soluble hederagenin glycoside also found in Hedera Helix extracts) have been studied. 

This in vitro testing shows that α-Hederin:

  • Inhibits internalization of occupied β2 adrenergic receptors.
  • Increases the binding affinity of noradrenaline for β2AR.
  • Increases intracellular cAMP (which confirms that it increased β2AR binding).

The increased binding potential of these receptors to other ligands when exposed to α-Hederin suggest that there exists potential for a synergistic effect between Hedera Helix extracts and β2AR agonists. This is, in my opinion, an extremely interesting and potentially very useful property."

Nutraplanet: "You've mentioned that hederagenin is a triterpene. I've heard that the bioavailability of triterpenes such as ursolic acid and oleanolic acid is very low. Has anything been done about this?"

Antaeus Labs: "Although the oral bioavailability of hederagenin is rightly described as ‘poor’ (probably between 0.8 and 2% when taken without dietary fats, and higher when taken with a meal) this is comparable to other similar triterpenoid compounds like ursolic acid.  Hederagenin's bioavailability is low, but it's far from zero, and I believe that hederagenin's low bioavailability is offset by its extremely high affinity for monoamine transporters. In any case, this is the reason a normal serving of Axon contains over two grams of Hedera Helix extract.

It's also worth mentioning the fact that hederagenin can be detected in the cerebrospinal fluid of rats after 20 minutes, indicating that hederagenin can pass through the blood-brain barrier. There's no indication, as some may presume, that the rat blood-brain barrier is any less permeable than the human blood-brain barrier. In fact, several studies have shown the opposite to be true. And although there's no data in humans, predictive models have shown us that hederagenin should be able to pass the human BBB without much difficulty"

Nutraplanet: "The Wikipedia page for hederagenin tells us that it's a pesticide. Is there any truth to this?"

Antaeus Labs: "That's true, and it probably puts some people off from the idea of taking it as a supplement – but it shouldn’t. Many other naturally-occurring plant-derived compounds have anti-microbial and anti-fungal properties. Resveratrol, for example, is one of the most popular supplements in both the sports and anti-aging circles, and has been successfully used as a topical pesticide. Caffeine is also a pesticide, as are many dozens of lesser-known herbal stimulants. These naturally-occurring compounds are safe for human consumption, and they should not be confused with synthetic organochloride insecticides. Hederagenin is not toxic to humans at any reasonable dose."

Nutraplanet: "How should I use Axon? When should I take it?"

Antaeus Labs: "Take 2-3 capsules with food, and don't take it within six hours of going to sleep. I believe that it's best to take a single daily dose with breakfast"

Nutraplanet: "Can Axon be stacked with other products?"

Antaeus Labs: "Absolutely! An ideal choice for fat-loss would be something like Vanillean. Axon also pairs well with nootropics, such as Demiurge and piracetam."

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


Customer Reviews for Axon (90 Caps) by Antaeus Labs

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  • Currently 5/5
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Real Customer.... By: Justo

Review posted on: 2014-02-20 05:48:01 -0500

...Axon is really good. For some people it can give them the bad jitters.I can tell you right away its not CAFFEINE overload.So many claim that this thing is pure caffeine but this feels different. It actually gives you that motivation and helps with mood especially on days you are feeling real sore and too tired to do anything from yesterday's work out. This will keep you going. =)

Axon Supplement Facts

Serving Size: 1 Capsule
Servings per Container: 90

 
  Amount Per Serving % Daily Value
Hederagenin ([3-beta,4-alpha]-3,23-dihydroxyolean-12-en-28-oic acid) 140 mg **
Caffeine 60 mg **
 

* Percent Daily Values are based on a 2000 calorie diet.
** Percent Daily Values not established.

OTHER INGREDIENTS: 

Axon Directions:

As a dietary supplement, take 2-3 capsules daily.

Axon WARNING:

DO NOT TAKE IN EXCESS OF ITS RECOMMENDED DOSAGE. This product intended only for healthy adults over 21 and may acutely elevate blood pressure and heart rate. Consult a licensed healthcare practitioner before use. Do not use if you are currently pregnant or nursing, have had or have a family history of heart disease, high blood pressure, stroke or any other disease, or using an MAOI, prescription drug, or over-the-counter drug, particularly for cold and sinus. If you are a competitive athlete and/or subject to drug testing, consult with your sanctioning body prior to use to ensure compliance. Discontinue use immediately if you experience any adverse reactions.